Late-onset isolated ACTH deficiency
ORPHA:199299АуруҚолданылмайдыЕресек
Фенотипы (HPO)41
Облигатный (100%)3
HP:0008163Decreased circulating cortisol level
HP:0011735Adrenocorticotropin deficient adrenal insufficiency
HP:0011748Adrenocorticotropic hormone deficiency
Очень частый (80–99%)13
HP:0001254Lethargy
HP:0001324Muscle weakness
HP:0001508Failure to thrive
HP:0001824Weight loss
HP:0002014Diarrhea
HP:0002017Nausea and vomiting
HP:0002019Constipation
HP:0002027Abdominal pain
HP:0002039Anorexia
HP:0002615Hypotension
HP:0002920Decreased circulating ACTH level
HP:0002960Autoimmunity
HP:0012378Fatigue
Частый (30–79%)9
HP:0000872Hashimoto thyroiditis
HP:0001897Normocytic anemia
HP:0001972Macrocytic anemia
HP:0002149Hyperuricemia
HP:0002902Hyponatremia
HP:0008209Premature ovarian insufficiency
HP:0011134Low-grade fever
HP:0100647Graves disease
HP:0100651Type I diabetes mellitus
Периодический (5–29%)13
HP:0000829Hypoparathyroidism
HP:0000958Dry skin
HP:0001045Vitiligo
HP:0001250Seizure
HP:0001278Orthostatic hypotension
HP:0001880Eosinophilia
HP:0001943Hypoglycemia
HP:0002321Vertigo
HP:0002608Celiac disease
HP:0002829Arthralgia
HP:0003072Hypercalcemia
HP:0006462Generalized bone demineralization
HP:0012115Hepatitis
Очень редкий (1–4%)2
HP:0002893Pituitary adenoma
HP:0100806Sepsis
Исключён (0%)1
HP:0002153Hyperkalemia
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)