Primary hepatic neuroendocrine carcinoma
ORPHA:100085DiseaseNot applicableAdult
Фенотипы (HPO)38
Облигатный (100%)2
HP:0002896Neoplasm of the liver
HP:0100634Neuroendocrine neoplasm
Частый (30–79%)12
HP:0001541Ascites
HP:0001824Weight loss
HP:0002014Diarrhea
HP:0002018Nausea
HP:0002039Anorexia
HP:0002094Dyspnea
HP:0002240Hepatomegaly
HP:0002574Episodic abdominal pain
HP:0002730Chronic noninfectious lymphadenopathy
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0003270Abdominal distention
HP:0012432Chronic fatigue
Периодический (5–29%)11
HP:4000007Bronchoconstriction
HP:0001407Hepatic cysts
HP:0001708Right ventricular failure
HP:0001962Palpitations
HP:0002480Hepatic encephalopathy
HP:0003144Increased serum serotonin
HP:0007380Facial telangiectasia
HP:0025474Erythematous plaque
HP:0030148Heart murmur
HP:0030166Night sweats
HP:0100570Carcinoid tumor
Очень редкий (1–4%)11
HP:0000508Ptosis
HP:0001046Intermittent jaundice
HP:0004375Neoplasm of the nervous system
HP:0005230Biliary tract obstruction
HP:0006575Intrahepatic cholestasis with episodic jaundice
HP:0007663Reduced visual acuity
HP:0010638Elevated alkaline phosphatase of hepatic origin
HP:0012658Abnormal brain FDG positron emission tomography
HP:0030948Elevated gamma-glutamyltransferase level
HP:0100012Neoplasm of the eye
HP:0100526Neoplasm of the lung
Исключён (0%)2
HP:0006254Elevated alpha-fetoprotein
HP:0031029Elevated carcinoembryonic antigen level
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.2 | Worldwide | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)