Multiple system atrophy

ORPHA:102DiseaseMultigenic/multifactorial, Not applicableAdult

Фенотипы (HPO)27

Частый (30–79%)27

HP:0000640Gaze-evoked nystagmus

HP:0001260Dysarthria

HP:0001300Parkinsonism

HP:0002019Constipation

HP:0002063Rigidity

HP:0002066Gait ataxia

HP:0002067Bradykinesia

HP:0002073Progressive cerebellar ataxia

HP:0002172Postural instability

HP:0002174Postural tremor

HP:0002310Orofacial dyskinesia

HP:0002322Resting tremor

HP:0002359Frequent falls

HP:0002494Abnormal rapid eye movement sleep

HP:0002530Axial dystonia

HP:0004926Orthostatic hypotension due to autonomic dysfunction

HP:0005341Autonomic bladder dysfunction

HP:0007256Abnormal pyramidal sign

HP:0008652Autonomic erectile dysfunction

HP:0010307Stridor

HP:0010536Central sleep apnea

HP:0012658Abnormal brain FDG positron emission tomography

HP:0012670Orthostatic syncope

HP:0030015Female anorgasmia

HP:0030880Raynaud phenomenon

HP:0100595Camptocormia

HP:0012332Abnormal autonomic nervous system physiology

Тип оценки	Класс распространённости	Среднее (на 100к)	Регион	Квалификация
Point prevalence	1-9 / 100 000	3.7	Europe	Value and class
Point prevalence	1-9 / 100 000	3.5	Worldwide	Value and class
Annual incidence	1-9 / 100 000	1.8	Worldwide	Value and class
Annual incidence	1-9 / 1 000 000	0.7	Iceland	Value and class
Point prevalence	1-9 / 100 000	3.4	Iceland	Value and class
Annual incidence	1-9 / 100 000	2.1	Sweden	Value and class
Point prevalence	1-9 / 100 000	4.4	United Kingdom	Value and class
Annual incidence	1-9 / 1 000 000	0.6	United States	Value and class
Point prevalence	1-9 / 100 000	1.9	France	Value and class
Annual incidence	1-9 / 1 000 000	0.11	Russian Federation	Value and class
Point prevalence	1-9 / 100 000	4.9	Italy	Value and class
Point prevalence	1-5 / 10 000	10.3	Japan	Value and class
Point prevalence	1-9 / 100 000	2.3	Faroe Islands	Value and class

Источник: Open Targets Platform (в реальном времени)

Источник: ClinicalTrials.gov (в реальном времени)