Brucellosis
ORPHA:1304DiseaseNot applicableAll ages
Фенотипы (HPO)77
Очень частый (80–99%)1
HP:0001392Abnormality of the liver
Частый (30–79%)19
HP:0000975Hyperhidrosis
HP:0001369Arthritis
HP:0001744Splenomegaly
HP:0001824Weight loss
HP:0001882Leukopenia
HP:0001903Anemia
HP:0001945Fever
HP:0002018Nausea
HP:0002039Anorexia
HP:0002240Hepatomegaly
HP:0002829Arthralgia
HP:0003095Septic arthritis
HP:0003237Increased circulating IgG level
HP:0003565Elevated erythrocyte sedimentation rate
HP:0011024Abnormality of the gastrointestinal tract
HP:0011227Elevated circulating C-reactive protein concentration
HP:0012378Fatigue
HP:0025155Abnormality of hepatobiliary system physiology
HP:0025406Asthenia
Периодический (5–29%)39
HP:0000031Epididymitis
HP:0000099Glomerulonephritis
HP:0000119Abnormality of the genitourinary system
HP:0000707Abnormality of the nervous system
HP:0000716Depression
HP:0000951Abnormality of the skin
HP:0000979Purpura
HP:0001508Failure to thrive
HP:0001518Small for gestational age
HP:0001622Premature birth
HP:0001873Thrombocytopenia
HP:0001971Hypersplenism
HP:0001974Leukocytosis
HP:0002011Morphological central nervous system abnormality
HP:0002013Vomiting
HP:0002027Abdominal pain
HP:0002090Pneumonia
HP:0002202Pleural effusion
HP:0002315Headache
HP:0002716Lymphadenopathy
HP:0002754Osteomyelitis
HP:0002923Rheumatoid factor positive
HP:0003496Increased circulating IgM level
HP:0005086Knee osteoarthritis
HP:0005268Spontaneous abortion
HP:0005561Abnormality of bone marrow cell morphology
HP:0008843Hip osteoarthritis
HP:0009830Peripheral neuropathy
HP:0012252Abnormal respiratory system morphology
HP:0012317Sacroiliac arthritis
HP:0012387Bronchitis
HP:0025143Chills
HP:0025245Cutaneous cyst
HP:0030350Erythematous papule
HP:0032252Granuloma
HP:0100326Immunologic hypersensitivity
HP:0100523Liver abscess
HP:0100796Orchitis
HP:0410008Abnormality of the peripheral nervous system
Очень редкий (1–4%)18
HP:0000708Atypical behavior
HP:0001626Abnormality of the cardiovascular system
HP:0001646Abnormal aortic valve morphology
HP:0001701Pericarditis
HP:0001894Thrombocytosis
HP:0002072Chorea
HP:0002326Transient ischemic attack
HP:0002383Infectious encephalitis
HP:0004418Thrombophlebitis
HP:0012089Arteritis
HP:0012122Anterior uveitis
HP:0012424Chorioretinitis
HP:0012819Myocarditis
HP:0025044Lung abscess
HP:0030250Pulmonary granulomatosis
HP:0031910Abnormal cranial nerve physiology
HP:0032620Intrarenal abscess
HP:0100584Endocarditis
Эпидемиология25
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | <1 / 1 000 000 | 0.09 | Europe | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.03 | France | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.04 | Austria | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.05 | Germany | Value and class |
| Annual incidence | 1-9 / 100 000 | 1.13 | Greece | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.03 | Ireland | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.22 | Italy | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.01 | Lithuania | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.03 | Luxembourg | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.05 | Malta | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.05 | Norway | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.35 | Portugal | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.12 | Spain | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.15 | Sweden | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.02 | United Kingdom | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.01 | Romania | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.02 | Slovakia | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.02 | Slovenia | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.02 | Netherlands | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.01 | Poland | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.04 | Belgium | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.11 | Bulgaria | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.02 | Croatia | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.004 | Czech Republic | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.008 | Finland | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)