Coarctation of aorta
ORPHA:1457Morphological anomalyNot applicableAdolescent, Adult, Childhood, Infancy, Neonatal
Фенотипы (HPO)18
Облигатный (100%)1
HP:0012305Coarctation of the descending aortic arch
Очень частый (80–99%)1
HP:0011103Abnormal left ventricular outflow tract morphology
Частый (30–79%)4
HP:0001640Cardiomegaly
HP:0001647Bicuspid aortic valve
HP:0001677Coronaryartery atherosclerosis
HP:0004383Hypoplastic left heart
Периодический (5–29%)6
HP:0000822Hypertension
HP:0001635Congestive heart failure
HP:0001643Patent ductus arteriosus
HP:0005301Persistent left superior vena cava
HP:0011682Perimembranous ventricular septal defect
HP:0012304Hypoplastic aortic arch
Очень редкий (1–4%)4
HP:0001297Stroke
HP:0001636Tetralogy of Fallot
HP:0002092Pulmonary arterial hypertension
HP:0010883Aortic valve atresia
Исключён (0%)2
HP:0005295Pseudocoarctation of the aorta
HP:0011611Interrupted aortic arch
Эпидемиология20
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Prevalence at birth | 1-5 / 10 000 | 35.6 | Europe | Value and class |
| Prevalence at birth | 6-9 / 10 000 | 78.5 | Austria | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 43.7 | Belgium | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 22.7 | Croatia | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 21.3 | Denmark | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 27.5 | France | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 59.4 | Germany | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 31 | Hungary | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 32.5 | Ireland | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 39.6 | Italy | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 24.9 | Malta | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 11.7 | Netherlands | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 21.3 | Norway | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 8 | Poland | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 9.5 | Portugal | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 16.9 | Spain | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 25.1 | Switzerland | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 40.1 | United Kingdom | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 38.1 | Ukraine | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)