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Crane-Heise syndrome

ORPHA:1512Malformation syndromeAutosomal recessiveAntenatal, Neonatal

Фенотипы (20)

Очень частый (80–99%)11
HP:0000175Cleft palate
HP:0000316Hypertelorism
HP:0000347Micrognathia
HP:0000463Anteverted nares
HP:0000882Hypoplastic scapulae
HP:0001511Intrauterine growth retardation
HP:0001762Talipes equinovarus
HP:0004331Decreased skull ossification
HP:0005280Depressed nasal bridge
HP:0006660Aplastic clavicles
HP:0000358Posteriorly rotated ears
Частый (30–79%)6
HP:0000028Cryptorchidism
HP:0001387Joint stiffness
HP:0001770Toe syndactyly
HP:0006101Finger syndactyly
HP:0009882Short distal phalanx of finger
HP:0100569Abnormally ossified vertebrae
Периодический (5–29%)3
HP:0002119Ventriculomegaly
HP:0007370Aplasia/Hypoplasia of the corpus callosum
HP:0008736Hypoplasia of penis

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы