Acquired hemophagocytic lymphohistiocytosis associated with malignant disease
ORPHA:158057Particular clinical situation in a disease or syndromeAll ages
Фенотипы (HPO)39
Облигатный (100%)1
HP:0012156Hemophagocytosis
Очень частый (80–99%)9
HP:0011117Abnormal circulating interleukin concentration
HP:0001744Splenomegaly
HP:0001876Pancytopenia
HP:0001945Fever
HP:0002958Immune dysregulation
HP:0003281Increased circulating ferritin concentration
HP:0011227Elevated circulating C-reactive protein concentration
HP:0012211Abnormal renal physiology
HP:0040218Reduced natural killer cell count
Частый (30–79%)9
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0004377Hematological neoplasm
HP:0011900Hypofibrinogenemia
HP:0025435Increased circulating lactate dehydrogenase concentration
HP:0001873Thrombocytopenia
HP:0001875Decreased total neutrophil count
HP:0001903Anemia
HP:0002155Hypertriglyceridemia
HP:0002904Hyperbilirubinemia
Периодический (5–29%)14
HP:0001399Hepatic failure
HP:0001433Hepatosplenomegaly
HP:0002863Myelodysplasia
HP:0002922Increased CSF protein concentration
HP:0004808Acute myeloid leukemia
HP:0005521Disseminated intravascular coagulation
HP:0006721Acute lymphoblastic leukemia
HP:0006775Multiple myeloma
HP:0012189Hodgkin lymphoma
HP:0012190T-cell lymphoma
HP:0012191B-cell lymphoma
HP:0012229CSF pleocytosis
HP:0020072Persistent EBV viremia
HP:0030080Burkitt lymphoma
Очень редкий (1–4%)6
HP:0001402Hepatocellular carcinoma
HP:0002667Nephroblastoma
HP:0002860Squamous cell carcinoma
HP:0003003Colon cancer
HP:0012125Prostate cancer
HP:0100526Neoplasm of the lung
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)