Macrophage activation syndrome
ORPHA:158061Clinical syndromeAdolescent, Adult, Childhood
Фенотипы (HPO)29
Очень частый (80–99%)17
HP:0001410Decreased liver function
HP:0001873Thrombocytopenia
HP:0001903Anemia
HP:0001945Fever
HP:0002960Autoimmunity
HP:0003073Hypoalbuminemia
HP:0003281Increased circulating ferritin concentration
HP:0003565Elevated erythrocyte sedimentation rate
HP:0011117Abnormal circulating interleukin concentration
HP:0011118Abnormality of tumor necrosis factor secretion
HP:0012156Hemophagocytosis
HP:0012649Increased inflammatory response
HP:0025435Increased circulating lactate dehydrogenase concentration
HP:0030356Increased serum interferon-gamma level
HP:0030783Increased circulating interleukin 6 concentration
HP:0031964Elevated circulating alanine aminotransferase concentration
HP:0040089Abnormal natural killer cell count
Частый (30–79%)8
HP:0001744Splenomegaly
HP:0001875Decreased total neutrophil count
HP:0002155Hypertriglyceridemia
HP:0002716Lymphadenopathy
HP:0005681Juvenile rheumatoid arthritis
HP:0011227Elevated circulating C-reactive protein concentration
HP:0011900Hypofibrinogenemia
HP:0031956Elevated circulating aspartate aminotransferase concentration
Периодический (5–29%)4
HP:0001298Encephalopathy
HP:0002240Hepatomegaly
HP:0002725Systemic lupus erythematosus
HP:0012115Hepatitis
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)