Infant botulism
ORPHA:178478Clinical subtypeInfancy, Neonatal
Фенотипы (HPO)28
Очень частый (80–99%)17
HP:0000217Xerostomia
HP:0000298Mask-like facies
HP:0000508Ptosis
HP:0000651Diplopia
HP:0001097Keratoconjunctivitis sicca
HP:0001252Hypotonia
HP:0001260Dysarthria
HP:0001620Abnormally high-pitched voice
HP:0002015Dysphagia
HP:0002019Constipation
HP:0002039Anorexia
HP:0002307Drooling
HP:0002360Sleep abnormality
HP:0006824Cranial nerve paralysis
HP:0011499Mydriasis
HP:0100021Cerebral palsy
HP:0100022Abnormality of movement
Частый (30–79%)7
HP:0000600Abnormality of the pharynx
HP:0000822Hypertension
HP:0001284Areflexia
HP:0002094Dyspnea
HP:0002607Bowel incontinence
HP:0002615Hypotension
HP:0002747Respiratory insufficiency due to muscle weakness
Периодический (5–29%)4
HP:0000389Chronic otitis media
HP:0001695Cardiac arrest
HP:0002027Abdominal pain
HP:0002902Hyponatremia
Эпидемиология5
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Prevalence at birth | 1-9 / 1 000 000 | 0.2 | Europe | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.3 | Europe | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 2.1 | United States | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 2.2 | Argentina | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)