Nelson syndrome
ORPHA:199244Clinical syndromeAdult, Elderly
Фенотипы (HPO)27
Облигатный (100%)2
HP:0011744Secondary hypercorticolism
HP:0011749Adrenocorticotropic hormone excess
Очень частый (80–99%)3
HP:0003118Increased circulating cortisol level
HP:0008291Pituitary corticotropic cell adenoma
HP:0012030Increased urinary cortisol level
Частый (30–79%)10
HP:0000505Visual impairment
HP:0000822Hypertension
HP:0001065Striae distensae
HP:0002900Hypokalemia
HP:0005978Type II diabetes mellitus
HP:0007340Lower limb muscle weakness
HP:0007440Generalized hyperpigmentation
HP:0007924Slow decrease in visual acuity
HP:0030521Bitemporal hemianopia
HP:0030591Abnormal kinetic perimetry test
Периодический (5–29%)5
HP:0000830Anterior hypopituitarism
HP:0002516Increased intracranial pressure
HP:0007807Optic nerve compression
HP:0009050Quadriceps muscle atrophy
HP:0012246Oculomotor nerve palsy
Очень редкий (1–4%)7
HP:0000870Increased circulating prolactin concentration
HP:0000873Diabetes insipidus
HP:0002170Intracranial hemorrhage
HP:0010788Testicular neoplasm
HP:0011763Pituitary carcinoma
HP:0200026Ocular pain
HP:0430022Abnormality of the sphenoid sinus
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)