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Progressive non-infectious anterior vertebral fusion

ORPHA:2062Malformation syndromeNot applicableChildhood

Фенотипы (27)

Очень частый (80–99%)18
HP:0000154Wide mouth
HP:0000233Thin vermilion border
HP:0000248Brachycephaly
HP:0000311Round face
HP:0000316Hypertelorism
HP:0000322Short philtrum
HP:0000347Micrognathia
HP:0000431Wide nasal bridge
HP:0000494Downslanted palpebral fissures
HP:0000925Abnormality of the vertebral column
HP:0001072Thickened skin
HP:0001176Large hands
HP:0002650Scoliosis
HP:0002808Kyphosis
HP:0002937Hemivertebrae
HP:0005108Abnormal intervertebral disk morphology
HP:0005280Depressed nasal bridge
HP:0012368Flat face
Периодический (5–29%)9
HP:0000098Tall stature
HP:0001387Joint stiffness
HP:0001999Abnormal facial shape
HP:0002011Morphological central nervous system abnormality
HP:0002653Bone pain
HP:0003306Spinal rigidity
HP:0003363Abdominal situs inversus
HP:0005037Proximal radio-ulnar synostosis
HP:0100777Exostoses

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы