Overlap myositis
ORPHA:206572DiseaseNot applicableAdult
Фенотипы (HPO)40
Частый (30–79%)21
HP:0000822Hypertension
HP:0001369Arthritis
HP:0002015Dysphagia
HP:0002960Autoimmunity
HP:0003119Abnormal circulating lipid concentration
HP:0003236Elevated circulating creatine kinase concentration
HP:0003493Antinuclear antibody positivity
HP:0003701Proximal muscle weakness
HP:0008997Proximal muscle weakness in upper limbs
HP:0011838Sclerodactyly
HP:0025131Finger swelling
HP:0025142Constitutional symptom
HP:0030859Anti-topoisomerase I antibody positivity
HP:0030880Raynaud phenomenon
HP:0032169Severe infection
HP:0033040Anti-Sm antibody positivity
HP:0033555Anti-Ro/SS-A antibody positivity
HP:0033560Anti-PM-Scl antibody positivity
HP:0034088Anti-Ku antibody positivity
HP:0034093Anti-Ro52/TRIM21 antibody positivity
HP:0100296Perifascicular muscle fiber atrophy
Периодический (5–29%)18
HP:0000077Abnormality of the kidney
HP:0000819Diabetes mellitus
HP:0001288Gait disturbance
HP:0001627Abnormal heart morphology
HP:0001873Thrombocytopenia
HP:0001882Leukopenia
HP:0002092Pulmonary arterial hypertension
HP:0002273Tetraparesis
HP:0002725Systemic lupus erythematosus
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0003549Abnormality of connective tissue
HP:0003551Difficulty climbing stairs
HP:0004269Subluxation of the small joints of the hand
HP:0006530Abnormal pulmonary interstitial morphology
HP:0009053Distal lower limb muscle weakness
HP:0009763Limb pain
HP:0011121Abnormal skin morphology
HP:0100324Scleroderma
Очень редкий (1–4%)1
HP:0001370Rheumatoid arthritis
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Europe | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)