Subacute inflammatory demyelinating polyneuropathy
ORPHA:206594DiseaseAll ages
Фенотипы (HPO)40
Очень частый (80–99%)5
HP:0000762Decreased nerve conduction velocity
HP:0001324Muscle weakness
HP:0002922Increased CSF protein concentration
HP:0003431Decreased motor nerve conduction velocity
HP:0007377Abnormality of somatosensory evoked potentials
Частый (30–79%)16
HP:0001284Areflexia
HP:0001288Gait disturbance
HP:0001974Leukocytosis
HP:0002359Frequent falls
HP:0003447Axonal loss
HP:0003474Somatic sensory dysfunction
HP:0003551Difficulty climbing stairs
HP:0003565Elevated erythrocyte sedimentation rate
HP:0004302Functional motor deficit
HP:0006881Diffuse peripheral demyelination
HP:0007078Decreased amplitude of sensory action potentials
HP:0007141Sensorimotor neuropathy
HP:0007220Demyelinating motor neuropathy
HP:0007262Symmetric peripheral demyelination
HP:0011096Peripheral demyelination
HP:0012531Pain
Периодический (5–29%)16
HP:0001266Choreoathetosis
HP:0001337Tremor
HP:0001430Abnormality of the calf musculature
HP:0002403Positive Romberg sign
HP:0002460Distal muscle weakness
HP:0002936Distal sensory impairment
HP:0003237Increased circulating IgG level
HP:0003376Steppage gait
HP:0003448Decreased sensory nerve conduction velocity
HP:0006376Limited elbow flexion
HP:0006844Absent patellar reflexes
HP:0007230Decreased distal sensory nerve action potential
HP:0008800Limited hip movement
HP:0010505Limitation of movement at ankles
HP:0012078Motor conduction block
HP:0032169Severe infection
Очень редкий (1–4%)3
HP:0002086Abnormality of the respiratory system
HP:0002270Abnormality of the autonomic nervous system
HP:0006824Cranial nerve paralysis
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)