Polyneuropathy associated with IgM monoclonal gammopathy
ORPHA:209004DiseaseNot applicableAdult, Elderly
Фенотипы (HPO)19
Очень частый (80–99%)3
HP:0002166Impaired vibration sensation in the lower limbs
HP:0007133Progressive peripheral neuropathy
HP:0011402Demyelinating sensory neuropathy
Частый (30–79%)7
HP:0002936Distal sensory impairment
HP:0003693Distal amyotrophy
HP:0007002Motor axonal neuropathy
HP:0007220Demyelinating motor neuropathy
HP:0007267Chronic axonal neuropathy
HP:0007340Lower limb muscle weakness
HP:0100287EMG: slow motor conduction
Периодический (5–29%)5
HP:0005508Monoclonal immunoglobulin M proteinemia
HP:0003390Sensory axonal neuropathy
HP:0007240Progressive gait ataxia
HP:0012514Lower limb pain
HP:0031006Acroparesthesia
Очень редкий (1–4%)4
HP:0002665Lymphoma
HP:0006775Multiple myeloma
HP:0025346Increased circulating beta-2-microglobulin level
HP:0100778Cryoglobulinemia
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
| Annual incidence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)