Progressive multifocal leukoencephalopathy
ORPHA:217260DiseaseNot applicableAll ages
Фенотипы (HPO)35
Очень частый (80–99%)8
HP:0000707Abnormality of the nervous system
HP:0002721Immunodeficiency
HP:0002921Abnormality of the cerebrospinal fluid
HP:0004302Functional motor deficit
HP:0007305CNS demyelination
HP:0031392Abnormal proportion of CD4 T cells
HP:0100706Abnormality of the oligodendroglia
HP:0100707Abnormal astrocyte morphology
Частый (30–79%)12
HP:0000505Visual impairment
HP:0001260Dysarthria
HP:0001268Mental deterioration
HP:0002066Gait ataxia
HP:0002167Abnormality of speech or vocalization
HP:0002315Headache
HP:0003474Somatic sensory dysfunction
HP:0003690Limb muscle weakness
HP:0004374Hemiplegia/hemiparesis
HP:0005415Decreased proportion of CD8-positive T cells
HP:0010549Weakness due to upper motor neuron dysfunction
HP:0100543Cognitive impairment
Периодический (5–29%)11
HP:0000639Nystagmus
HP:0000751Personality changes
HP:0001123Visual field defect
HP:0001250Seizure
HP:0001300Parkinsonism
HP:0002321Vertigo
HP:0002381Aphasia
HP:0004377Hematological neoplasm
HP:0012246Oculomotor nerve palsy
HP:0025479Self-neglect
HP:0030516Homonymous hemianopia
Очень редкий (1–4%)4
HP:0000651Diplopia
HP:0001287Meningitis
HP:0001310Dysmetria
HP:0003401Paresthesia
Эпидемиология3
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
| Annual incidence | <1 / 1 000 000 | 0.068 | Sweden | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.11 | France | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)