Insulin-resistance syndrome type B
ORPHA:2298DiseaseNot applicableAdolescent, Adult, Childhood, Elderly
Фенотипы (HPO)50
Очень частый (80–99%)14
HP:0000842Hyperinsulinemia
HP:0000855Insulin resistance
HP:0000956Acanthosis nigricans
HP:0001824Weight loss
HP:0001952Glucose intolerance
HP:0002725Systemic lupus erythematosus
HP:0002960Autoimmunity
HP:0003074Hyperglycemia
HP:0003565Elevated erythrocyte sedimentation rate
HP:0004359Abnormal circulating fatty-acid concentration
HP:0004924Abnormal oral glucose tolerance
HP:0008283Fasting hyperinsulinemia
HP:0011998Postprandial hyperglycemia
HP:0012153Hypotriglyceridemia
Частый (30–79%)19
HP:0000093Proteinuria
HP:0000123Nephritis
HP:0000147Polycystic ovaries
HP:0000831Insulin-resistant diabetes mellitus
HP:0001007Hirsutism
HP:0001882Leukopenia
HP:0003073Hypoalbuminemia
HP:0003076Glycosuria
HP:0003119Abnormal circulating lipid concentration
HP:0003493Antinuclear antibody positivity
HP:0004323Abnormality of body weight
HP:0004325Decreased body weight
HP:0004361Abnormality of circulating leptin level
HP:0005416Decreased serum complement factor B
HP:0005978Type II diabetes mellitus
HP:0008675Enlarged polycystic ovaries
HP:0012378Fatigue
HP:0030088Increased serum testosterone level
HP:0100879Enlarged ovaries
Периодический (5–29%)17
HP:0000825Hyperinsulinemic hypoglycemia
HP:0000988Skin rash
HP:0001596Alopecia
HP:0001873Thrombocytopenia
HP:0001946Ketosis
HP:0001953Diabetic ketoacidosis
HP:0002090Pneumonia
HP:0002613Biliary cirrhosis
HP:0002665Lymphoma
HP:0002758Osteoarthritis
HP:0003162Fasting hypoglycemia
HP:0003237Increased circulating IgG level
HP:0003261Increased circulating IgA level
HP:0004324Increased body weight
HP:0006775Multiple myeloma
HP:0010286Abnormal salivary gland morphology
HP:0012189Hodgkin lymphoma
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)