Asbestos intoxication
ORPHA:2302DiseaseAll ages
Фенотипы (HPO)35
Частый (30–79%)15
HP:0002086Abnormality of the respiratory system
HP:0002091Restrictive ventilatory defect
HP:0002094Dyspnea
HP:0002207Diffuse reticular or finely nodular infiltrations
HP:0002792Reduced vital capacity
HP:0002875Exertional dyspnea
HP:0003546Exercise intolerance
HP:0006530Abnormal pulmonary interstitial morphology
HP:0030874Oxygen desaturation on exertion
HP:0031246Nonproductive cough
HP:0031631Subpleural honeycombing
HP:0031944Pleural thickening
HP:0031998Late inspiratory crackles
HP:0032341Reduced forced vital capacity
HP:0045051Decreased DLCO
Периодический (5–29%)14
HP:0000961Cyanosis
HP:0001648Cor pulmonale
HP:0001708Right ventricular failure
HP:0002206Pulmonary fibrosis
HP:0002878Respiratory failure
HP:0012418Hypoxemia
HP:0025179Ground-glass opacification on pulmonary HRCT
HP:0030828Wheezing
HP:0030849Hepatojugular reflux
HP:0030879Interlobular septal thickening on pulmonary HRCT
HP:0031352Chest tightness
HP:0032016Abnormal sputum
HP:0100749Chest pain
HP:0100759Clubbing of fingers
Очень редкий (1–4%)6
HP:0000969Edema
HP:0001685Myocardial fibrosis
HP:0030078Lung adenocarcinoma
HP:0100001Malignant mesothelioma
HP:0100721Mediastinal lymphadenopathy
HP:0100750Atelectasis
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)