POEMS syndrome
ORPHA:2905DiseaseUnknownAdult, Elderly
Фенотипы (HPO)51
Облигатный (100%)1
HP:0001271Polyneuropathy
Очень частый (80–99%)6
HP:0000135Hypogonadism
HP:0000818Abnormality of the endocrine system
HP:0003271Visceromegaly
HP:0005523Lymphoproliferative disorder
HP:0010702Increased circulating antibody level
HP:0011122Abnormality of skin physiology
Частый (30–79%)33
HP:0000771Gynecomastia
HP:0000819Diabetes mellitus
HP:0000821Hypothyroidism
HP:0000953Hyperpigmentation of the skin
HP:0000969Edema
HP:0000998Hypertrichosis
HP:0001028Hemangioma
HP:0001072Thickened skin
HP:0001085Papilledema
HP:0001284Areflexia
HP:0001324Muscle weakness
HP:0001541Ascites
HP:0001698Pericardial effusion
HP:0001744Splenomegaly
HP:0001820Leukonychia
HP:0001824Weight loss
HP:0001894Thrombocytosis
HP:0002092Pulmonary arterial hypertension
HP:0002202Pleural effusion
HP:0002240Hepatomegaly
HP:0002694Sclerosis of skull base
HP:0002716Lymphadenopathy
HP:0003401Paresthesia
HP:0004054Sclerosis of hand bone
HP:0004576Sclerotic vertebral endplates
HP:0004979Metaphyseal sclerosis
HP:0008207Primary adrenal insufficiency
HP:0012378Fatigue
HP:0012531Pain
HP:0031052Elevated vascular endothelial growth factor level
HP:0100639Erectile dysfunction
HP:0100759Clubbing of fingers
HP:0100925Sclerosis of foot bone
Периодический (5–29%)11
HP:0000870Increased circulating prolactin concentration
HP:0001050Plethora
HP:0001063Acrocyanosis
HP:0001901Polycythemia
HP:0002091Restrictive ventilatory defect
HP:0002747Respiratory insufficiency due to muscle weakness
HP:0004420Arterial thrombosis
HP:0004936Venous thrombosis
HP:0009125Lipodystrophy
HP:0031357Glomeruloid hemangioma
HP:0100963Hyperesthesia
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Europe | Class only |
| Point prevalence | 1-9 / 1 000 000 | 0.33 | Japan | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)