Acute generalized exanthematous pustulosis
ORPHA:293173DiseaseMultigenic/multifactorial, Not applicableAll ages
Фенотипы (HPO)23
Очень частый (80–99%)2
HP:0001974Leukocytosis
HP:0200039Pustule
Частый (30–79%)7
HP:0000989Pruritus
HP:0001880Eosinophilia
HP:0001945Fever
HP:0003565Elevated erythrocyte sedimentation rate
HP:0011897Neutrophilia
HP:0032022Eosinophilic dermal infiltration
HP:0040189Scaling skin
Периодический (5–29%)10
HP:0000083Renal insufficiency
HP:0000282Facial edema
HP:0000979Purpura
HP:0001396Cholestasis
HP:0002094Dyspnea
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0031236Predominantly dermal neutrophilic infiltrate
HP:0100792Acantholysis
HP:0100825Cheilitis
HP:0200037Skin vesicle
Очень редкий (1–4%)4
HP:0000509Conjunctivitis
HP:0000953Hyperpigmentation of the skin
HP:0001875Decreased total neutrophil count
HP:0002716Lymphadenopathy
Эпидемиология3
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.3 | Worldwide | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.035 | Israel | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)