Manganese poisoning
ORPHA:306682DiseaseAll ages
Фенотипы (HPO)30
Очень частый (80–99%)15
HP:0000712Emotional lability
HP:0001276Hypertonia
HP:0001288Gait disturbance
HP:0001332Dystonia
HP:0002067Bradykinesia
HP:0002071Abnormality of extrapyramidal motor function
HP:0002172Postural instability
HP:0002174Postural tremor
HP:0002315Headache
HP:0002354Memory impairment
HP:0002396Cogwheel rigidity
HP:0002453Abnormal globus pallidus morphology
HP:0003287Abnormality of mitochondrial metabolism
HP:0006979Sleep-wake cycle disturbance
HP:0025464Increased reactive oxygen species production
Частый (30–79%)10
HP:0000505Visual impairment
HP:0000718Aggressive behavior
HP:0000722Compulsive behaviors
HP:0000746Delusion
HP:0000748Inappropriate laughter
HP:0000802Impotence
HP:0001289Confusion
HP:0002304Akinesia
HP:0030018Decreased female libido
HP:0040306Decreased male libido
Периодический (5–29%)5
HP:0000716Depression
HP:0000737Irritability
HP:0000738Hallucinations
HP:0031466Impairment in personality functioning
HP:5200321Amplification of sexual behavior
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)