Somatomammotropinoma
ORPHA:314769DiseaseAdolescent, Adult
Фенотипы (HPO)60
Очень частый (80–99%)26
HP:0000098Tall stature
HP:0000158Macroglossia
HP:0000179Thick lower lip vermilion
HP:0000276Long face
HP:0000280Coarse facial features
HP:0000293Full cheeks
HP:0000303Mandibular prognathia
HP:0000337Broad forehead
HP:0000400Macrotia
HP:0000445Wide nose
HP:0000830Anterior hypopituitarism
HP:0000845Elevated circulating growth hormone concentration
HP:0000870Increased circulating prolactin concentration
HP:0000975Hyperhidrosis
HP:0001072Thickened skin
HP:0001176Large hands
HP:0001182Tapered finger
HP:0001386Joint swelling
HP:0001769Broad foot
HP:0001869Deep plantar creases
HP:0002758Osteoarthritis
HP:0002829Arthralgia
HP:0003859Cortical diaphyseal thickening of the upper limbs
HP:0004099Macrodactyly
HP:0006191Deep palmar crease
HP:0012378Fatigue
Частый (30–79%)27
HP:0000044Hypogonadotropic hypogonadism
HP:0000141Amenorrhea
HP:0000164Abnormality of the dentition
HP:0000664Synophrys
HP:0000687Widely spaced teeth
HP:0000716Depression
HP:0000739Anxiety
HP:0000819Diabetes mellitus
HP:0000822Hypertension
HP:0001231Abnormal fingernail morphology
HP:0001609Hoarse voice
HP:0002007Frontal bossing
HP:0002076Migraine
HP:0002230Generalized hirsutism
HP:0002808Kyphosis
HP:0002893Pituitary adenoma
HP:0003401Paresthesia
HP:0003416Spinal canal stenosis
HP:0006767Pituitary prolactin cell adenoma
HP:0008388Abnormal toenail morphology
HP:0010535Sleep apnea
HP:0011760Pituitary growth hormone cell adenoma
HP:0012802Broad jaw
HP:0100021Cerebral palsy
HP:0100540Palpebral edema
HP:0100607Dysmenorrhea
HP:0100829Galactorrhea
Периодический (5–29%)7
HP:0000802Impotence
HP:0000956Acanthosis nigricans
HP:0001639Hypertrophic cardiomyopathy
HP:0001653Mitral regurgitation
HP:0007440Generalized hyperpigmentation
HP:0100518Dysuria
HP:0100786Hypersomnia
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)