Lujo hemorrhagic fever
ORPHA:319213DiseaseAll ages
Фенотипы (HPO)59
Очень частый (80–99%)10
HP:0000282Facial edema
HP:0001873Thrombocytopenia
HP:0001945Fever
HP:0002014Diarrhea
HP:0002315Headache
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0003326Myalgia
HP:0025258Stiff neck
HP:0025439Pharyngitis
HP:0031691Severe viral infection
Частый (30–79%)22
HP:0000083Renal insufficiency
HP:0000707Abnormality of the nervous system
HP:0000988Skin rash
HP:0001259Coma
HP:0001289Confusion
HP:0001882Leukopenia
HP:0001888Lymphopenia
HP:0001942Metabolic acidosis
HP:0001974Leukocytosis
HP:0002013Vomiting
HP:0002018Nausea
HP:0002907Microscopic hematuria
HP:0003645Prolonged partial thromboplastin time
HP:0007430Generalized edema
HP:0011227Elevated circulating C-reactive protein concentration
HP:0011896Subconjunctival hemorrhage
HP:0025435Increased circulating lactate dehydrogenase concentration
HP:0031273Shock
HP:0031364Ecchymosis
HP:0040186Maculopapular exanthema
HP:0100520Oliguria
HP:0100749Chest pain
Периодический (5–29%)27
HP:0000613Photophobia
HP:0000739Anxiety
HP:0000975Hyperhidrosis
HP:0000979Purpura
HP:0001250Seizure
HP:0001268Mental deterioration
HP:0001324Muscle weakness
HP:0001662Bradycardia
HP:0002015Dysphagia
HP:0002069Bilateral tonic-clonic seizure
HP:0002098Respiratory distress
HP:0002181Cerebral edema
HP:0002322Resting tremor
HP:0002329Drowsiness
HP:0002615Hypotension
HP:0004787Fulminant hepatitis
HP:0009830Peripheral neuropathy
HP:0012384Rhinitis
HP:0012819Myocarditis
HP:0025145Rigors
HP:0030139Excessive bleeding after a venipuncture
HP:0030830Crackles
HP:0031246Nonproductive cough
HP:0032043Odynophagia
HP:0032155Abdominal cramps
HP:0100539Periorbital edema
HP:0100750Atelectasis
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Cases/families | — | 5 | Worldwide | Case(s) |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)