Wild type ATTR amyloidosis
ORPHA:330001DiseaseNot applicableAdult, Elderly
Фенотипы (HPO)32
Очень частый (80–99%)9
HP:0001635Congestive heart failure
HP:0001639Hypertrophic cardiomyopathy
HP:0001658Myocardial infarction
HP:0002202Pleural effusion
HP:0003115Abnormal EKG
HP:0006530Abnormal pulmonary interstitial morphology
HP:0010741Pedal edema
HP:0031327Transthyretin cardiac amyloidosis
HP:0100598Pulmonary edema
Частый (30–79%)15
HP:0000763Sensory neuropathy
HP:0002028Chronic diarrhea
HP:0002240Hepatomegaly
HP:0002254Intermittent diarrhea
HP:0002495Impaired vibratory sensation
HP:0002579Gastrointestinal dysmotility
HP:0002607Bowel incontinence
HP:0003155Elevated circulating alkaline phosphatase concentration
HP:0004926Orthostatic hypotension due to autonomic dysfunction
HP:0005110Atrial fibrillation
HP:0005341Autonomic bladder dysfunction
HP:0011675Arrhythmia
HP:0012185Constrictive median neuropathy
HP:0012332Abnormal autonomic nervous system physiology
HP:0200101Decreased/absent ankle reflexes
Периодический (5–29%)8
HP:0000083Renal insufficiency
HP:0000093Proteinuria
HP:0000100Nephrotic syndrome
HP:0000112Nephropathy
HP:0001650Aortic valve stenosis
HP:0001662Bradycardia
HP:0001824Weight loss
HP:0003416Spinal canal stenosis
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 1.72 | Worldwide | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)