Lead poisoning
ORPHA:330015DiseaseNot applicableAll ages
Фенотипы (HPO)62
Частый (30–79%)8
HP:0000822Hypertension
HP:0002013Vomiting
HP:0002018Nausea
HP:0002019Constipation
HP:0002027Abdominal pain
HP:0002039Anorexia
HP:0003270Abdominal distention
HP:0012378Fatigue
Периодический (5–29%)26
HP:0000124Renal tubular dysfunction
HP:0000684Delayed eruption of teeth
HP:0000708Atypical behavior
HP:0000716Depression
HP:0000988Skin rash
HP:0001328Specific learning disability
HP:0001518Small for gestational age
HP:0001622Premature birth
HP:0001903Anemia
HP:0002315Headache
HP:0002354Memory impairment
HP:0002460Distal muscle weakness
HP:0002715Abnormality of the immune system
HP:0002795Abnormal respiratory system physiology
HP:0005268Spontaneous abortion
HP:0005560Imbalanced hemoglobin synthesis
HP:0007010Poor fine motor coordination
HP:0007015Poor gross motor coordination
HP:0007018Attention deficit hyperactivity disorder
HP:0031058Impairment of activities of daily living
HP:0032155Abdominal cramps
HP:0100511Abnormality of vitamin D metabolism
HP:0100512Low levels of vitamin D
HP:0100543Cognitive impairment
HP:0100602Preeclampsia
HP:0100785Insomnia
Очень редкий (1–4%)28
HP:0000140Abnormality of the menstrual cycle
HP:0000789Infertility
HP:0000798Oligozoospermia
HP:0000823Delayed puberty
HP:0001249Intellectual disability
HP:0001250Seizure
HP:0001259Coma
HP:0001298Encephalopathy
HP:0001970Tubulointerstitial nephritis
HP:0002099Asthma
HP:0002270Abnormality of the autonomic nervous system
HP:0002750Delayed skeletal maturation
HP:0002843Abnormal T cell morphology
HP:0003141Increased LDL cholesterol concentration
HP:0003212Increased circulating IgE level
HP:0003233Decreased HDL cholesterol concentration
HP:0003474Somatic sensory dysfunction
HP:0004437Cranial hyperostosis
HP:0005368Abnormality of humoral immunity
HP:0007178Motor polyneuropathy
HP:0009830Peripheral neuropathy
HP:0012207Reduced sperm motility
HP:0012622Chronic kidney disease
HP:0012760Reduced social responsiveness
HP:0012864Abnormal sperm morphology
HP:0030018Decreased female libido
HP:0031429Decreased circulating osteocalcin level
HP:0040306Decreased male libido
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 2.3 | Europe | Value and class |
| Point prevalence | 1-9 / 1 000 000 | 0.68 | France | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)