Neonatal lupus erythematosus
ORPHA:398124DiseaseNot applicableNeonatal
Фенотипы (HPO)36
Очень частый (80–99%)1
HP:0030057Autoimmune antibody positivity
Частый (30–79%)3
HP:0000951Abnormality of the skin
HP:0001392Abnormality of the liver
HP:0001871Abnormality of blood and blood-forming tissues
Периодический (5–29%)18
HP:0000238Hydrocephalus
HP:0000962Hyperkeratosis
HP:0000988Skin rash
HP:0000992Cutaneous photosensitivity
HP:0001036Parakeratosis
HP:0001644Dilated cardiomyopathy
HP:0001678Atrioventricular block
HP:0001873Thrombocytopenia
HP:0001875Decreased total neutrophil count
HP:0001903Anemia
HP:0002240Hepatomegaly
HP:0002500Abnormal cerebral white matter morphology
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0011675Arrhythmia
HP:0012722Heart block
HP:0025300Malar rash
HP:0025474Erythematous plaque
HP:0040186Maculopapular exanthema
Очень редкий (1–4%)13
HP:0000256Macrocephaly
HP:0001399Hepatic failure
HP:0001627Abnormal heart morphology
HP:0001657Prolonged QT interval
HP:0001744Splenomegaly
HP:0001876Pancytopenia
HP:0001878Hemolytic anemia
HP:0001892Abnormal bleeding
HP:0001915Aplastic anemia
HP:0002086Abnormality of the respiratory system
HP:0002135Basal ganglia calcification
HP:0002652Skeletal dysplasia
HP:0011702Abnormal electrophysiology of sinoatrial node origin
Исключён (0%)1
HP:0001396Cholestasis
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Prevalence at birth | 1-9 / 100 000 | 5 | United States | Value and class |
| Point prevalence | 1-9 / 1 000 000 | 5 | United States | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)