Lambert-Eaton myasthenic syndrome
ORPHA:43393DiseaseNot applicableAdult
Фенотипы (HPO)16
Очень частый (80–99%)7
HP:0000217Xerostomia
HP:0001315Reduced tendon reflexes
HP:0003403EMG: decremental response of compound muscle action potential to repetitive nerve stimulation
HP:0009073Progressive proximal muscle weakness
HP:0012332Abnormal autonomic nervous system physiology
HP:0030000EMG: repetitive nerve stimulation abnormality
HP:0030209Calcium channel antibody positivity
Частый (30–79%)6
HP:0000315Abnormality of the orbital region
HP:0000802Impotence
HP:0002019Constipation
HP:0002483Bulbar signs
HP:0030357Small cell lung carcinoma
HP:5000027Anti-P/Q-type VGCC antibody positivity
Периодический (5–29%)3
HP:0000966Hypohidrosis
HP:0001097Keratoconjunctivitis sicca
HP:0004926Orthostatic hypotension due to autonomic dysfunction
Эпидемиология3
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | <1 / 1 000 000 | 0.06 | Netherlands | Value and class |
| Point prevalence | 1-9 / 100 000 | 1 | Europe | Value and class |
| Point prevalence | 1-9 / 1 000 000 | 0.35 | Worldwide | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)