IgG4-related ophthalmic disease
ORPHA:449563Clinical subtypeNot applicableAdult, Elderly
Фенотипы (HPO)42
Частый (30–79%)16
HP:0000315Abnormality of the orbital region
HP:0000620Dacryocystitis
HP:0001733Pancreatitis
HP:0001880Eosinophilia
HP:0002716Lymphadenopathy
HP:0003212Increased circulating IgE level
HP:0003493Antinuclear antibody positivity
HP:0007734Enlarged lacrimal glands
HP:0010824Abnormal fifth cranial nerve morphology
HP:0011227Elevated circulating C-reactive protein concentration
HP:0011482Abnormal lacrimal gland morphology
HP:0012393Allergy
HP:0031281Sialadenitis
HP:0032300Increased circulating IgG4 level
HP:0100539Periorbital edema
HP:3000061Abnormality of infra-orbital nerve
Периодический (5–29%)12
HP:0000077Abnormality of the kidney
HP:0000246Sinusitis
HP:0000492Abnormal eyelid morphology
HP:0000496Abnormality of eye movement
HP:0000587Abnormal optic nerve morphology
HP:0002088Abnormal lung morphology
HP:0005200Retroperitoneal fibrosis
HP:0008049Abnormality of the extraocular muscles
HP:0009831Mononeuropathy
HP:0030669Abnormal ocular adnexa morphology
HP:0100540Palpebral edema
HP:3000030Abnormal morphology of bony orbit of skull
Очень редкий (1–4%)14
HP:0000024Prostatitis
HP:0000491Keratitis
HP:0000579Nasolacrimal duct obstruction
HP:0002665Lymphoma
HP:0003003Colon cancer
HP:0011747Abnormality of the anterior pituitary
HP:0012539Non-Hodgkin lymphoma
HP:0030151Cholangitis
HP:0031912Trigeminal anesthesia
HP:0100526Neoplasm of the lung
HP:0100646Thyroiditis
HP:0100661Trigeminal neuralgia
HP:0100796Orchitis
HP:0430022Abnormality of the sphenoid sinus
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)