TAFRO syndrome
ORPHA:457077DiseaseNot applicableAdolescent, Adult, Elderly
Фенотипы (HPO)25
Очень частый (80–99%)5
HP:0001433Hepatosplenomegaly
HP:0001873Thrombocytopenia
HP:0002716Lymphadenopathy
HP:0011227Elevated circulating C-reactive protein concentration
HP:0012050Anasarca
Частый (30–79%)13
HP:0000083Renal insufficiency
HP:0001541Ascites
HP:0001744Splenomegaly
HP:0001903Anemia
HP:0001945Fever
HP:0001974Leukocytosis
HP:0002202Pleural effusion
HP:0002240Hepatomegaly
HP:0003155Elevated circulating alkaline phosphatase concentration
HP:0005513Increased megakaryocyte count
HP:0011974Myelofibrosis
HP:0030783Increased circulating interleukin 6 concentration
HP:0031052Elevated vascular endothelial growth factor level
Периодический (5–29%)1
HP:0045041Reduced circulating lactate dehydrogenase concentration
Исключён (0%)6
HP:0002664Neoplasm
HP:0002960Autoimmunity
HP:0012156Hemophagocytosis
HP:0031691Severe viral infection
HP:0032262Pulmonary tuberculosis
HP:0032288Polyclonal elevation of circulating IgG
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Cases/families | — | 28 | Worldwide | Case(s) |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)