Catastrophic antiphospholipid syndrome
ORPHA:464343DiseaseNot applicableAdult
Фенотипы (HPO)52
Облигатный (100%)1
HP:0003613Antiphospholipid antibody positivity
Очень частый (80–99%)1
HP:0001977Abnormal thrombosis
Частый (30–79%)11
HP:0001937Microangiopathic hemolytic anemia
HP:0002625Deep venous thrombosis
HP:0002641Peripheral thrombosis
HP:0002829Arthralgia
HP:0004420Arterial thrombosis
HP:0004844Coombs-positive hemolytic anemia
HP:0004936Venous thrombosis
HP:0005268Spontaneous abortion
HP:0011112Abnormality of serum cytokine level
HP:0020136Anticardiolipin IgG antibody positivity
HP:0032376Anti-beta 2 glycoprotein I antibody positivity
Периодический (5–29%)26
HP:0000707Abnormality of the nervous system
HP:0000965Cutis marmorata
HP:0001250Seizure
HP:0001297Stroke
HP:0001369Arthritis
HP:0001654Abnormal heart valve morphology
HP:0001658Myocardial infarction
HP:0001873Thrombocytopenia
HP:0002076Migraine
HP:0002204Pulmonary embolism
HP:0002326Transient ischemic attack
HP:0002638Superficial thrombophlebitis
HP:0002725Systemic lupus erythematosus
HP:0020137Anticardiolipin IgM antibody positivity
HP:0025324Arterial occlusion
HP:0025343Lupus anticoagulant
HP:0031653Abnormal heart valve physiology
HP:0034084Anti-phosphatidyl ethanolamine antibody positivity
HP:0034097Anti-phosphatidyl choline antibody positivity
HP:0034098Anti-phosphatidyl glycerol antibody positivity
HP:0034099Anti-phosphatidyl inositol antibody positivity
HP:0034100Anti-phosphatidyl serine antibody positivity
HP:0034101Anti-annexin-V antibody positivity
HP:0100576Amaurosis fugax
HP:0100602Preeclampsia
HP:0200042Skin ulcer
Очень редкий (1–4%)13
HP:0001681Angina pectoris
HP:0002072Chorea
HP:0002092Pulmonary arterial hypertension
HP:0005244Gastrointestinal infarctions
HP:0006846Acute encephalopathy
HP:0010885Avascular necrosis
HP:0012819Myocarditis
HP:0025326Retinal arterial occlusion
HP:0100601Eclampsia
HP:0100758Gangrene
HP:3000042Abnormal jugular vein morphology
HP:0000077Abnormality of the kidney
HP:0000726Dementia
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)