Congenital syphilis
ORPHA:499009DiseaseNot applicableAntenatal, Neonatal
Фенотипы (HPO)46
Частый (30–79%)11
HP:0000967Petechiae
HP:0000979Purpura
HP:0001433Hepatosplenomegaly
HP:0001622Premature birth
HP:0001789Hydrops fetalis
HP:0001873Thrombocytopenia
HP:0001978Extramedullary hematopoiesis
HP:0006267Large placenta
HP:0040165Periostitis
HP:0040186Maculopapular exanthema
HP:0040188Osteochondrosis
Периодический (5–29%)27
HP:0000100Nephrotic syndrome
HP:0000218High palate
HP:0000365Hearing impairment
HP:0000491Keratitis
HP:0000501Glaucoma
HP:0000518Cataract
HP:0000554Uveitis
HP:0001511Intrauterine growth retardation
HP:0001733Pancreatitis
HP:0001903Anemia
HP:0002007Frontal bossing
HP:0002014Diarrhea
HP:0002024Malabsorption
HP:0002090Pneumonia
HP:0002716Lymphadenopathy
HP:0006579Prolonged neonatal jaundice
HP:0011092Mulberry molar
HP:0012229CSF pleocytosis
HP:0012384Rhinitis
HP:0012413Notched primary central incisor
HP:0012424Chorioretinitis
HP:0012758Neurodevelopmental delay
HP:0012819Myocarditis
HP:0025524Palmoplantar scaling skin
HP:0033782Semilunar tooth
HP:0100769Synovitis
HP:0430028Hyperplasia of the maxilla
Очень редкий (1–4%)8
HP:0000238Hydrocephalus
HP:0000648Optic atrophy
HP:0001250Seizure
HP:0001287Meningitis
HP:0001943Hypoglycemia
HP:0002982Tibial bowing
HP:0006824Cranial nerve paralysis
HP:0011120Concave nasal ridge
Эпидемиология17
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 1.3 | Europe | Value and class |
| Point prevalence | 1-5 / 10 000 | 15.7 | United States | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 15.7 | United States | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 1.3 | Europe | Value and class |
| Prevalence at birth | 1-5 / 10 000 | 26.6 | Bulgaria | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 1.3 | Czech Republic | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 1.04 | Denmark | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 1.1 | Greece | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 1.7 | Hungary | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 1.1 | Italy | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 4.6 | Lithuania | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 1.9 | Poland | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 5.4 | Portugal | Value and class |
| Prevalence at birth | 1-9 / 100 000 | 2.5 | Romania | Value and class |
| Prevalence at birth | 1-9 / 1 000 000 | 0.3 | Sweden | Value and class |
| Prevalence at birth | 1-9 / 1 000 000 | 0.3 | Germany | Value and class |
| Prevalence at birth | 1-9 / 1 000 000 | 0.8 | Spain | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)