Pediatric-onset Graves disease
ORPHA:525731DiseaseAdolescent, Childhood, Infancy
Фенотипы (HPO)48
Очень частый (80–99%)5
HP:0002960Autoimmunity
HP:0011703Sinus tachycardia
HP:0011784Thyrotoxicosis with diffuse goiter
HP:0031506Increased circulating thyroxine level
HP:0100647Graves disease
Частый (30–79%)24
HP:0000237Small anterior fontanelle
HP:0000492Abnormal eyelid morphology
HP:0000520Proptosis
HP:0000712Emotional lability
HP:0000737Irritability
HP:0000752Hyperactivity
HP:0000853Goiter
HP:0000975Hyperhidrosis
HP:0001337Tremor
HP:0001508Failure to thrive
HP:0001744Splenomegaly
HP:0001959Polydipsia
HP:0001962Palpitations
HP:0002014Diarrhea
HP:0002240Hepatomegaly
HP:0002487Hyperkinetic movements
HP:0002591Polyphagia
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0005616Accelerated skeletal maturation
HP:0008373Puberty and gonadal disorders
HP:0011788Increased circulating free T3
HP:0025379Anti-thyroid peroxidase antibody positivity
HP:0031284Flushing
HP:0100785Insomnia
Периодический (5–29%)12
HP:0000708Atypical behavior
HP:0000822Hypertension
HP:0000952Jaundice
HP:0001363Craniosynostosis
HP:0001511Intrauterine growth retardation
HP:0001562Oligohydramnios
HP:0001622Premature birth
HP:0001873Thrombocytopenia
HP:0002017Nausea and vomiting
HP:0005110Atrial fibrillation
HP:0010519Increased fetal movement
HP:0100534Episcleritis
Очень редкий (1–4%)7
HP:0000252Microcephaly
HP:0000491Keratitis
HP:0001263Global developmental delay
HP:0001635Congestive heart failure
HP:0001904Neutropenia in presence of anti-neutropil antibodies
HP:0012768Neonatal asphyxia
HP:0200028Pretibial myxedema
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)