CAR T cell therapy-associated cytokine release syndrome
ORPHA:542323Particular clinical situation in a disease or syndromeAdult
Фенотипы (HPO)31
Очень частый (80–99%)5
HP:0001945Fever
HP:0011112Abnormality of serum cytokine level
HP:0011117Abnormal circulating interleukin concentration
HP:0012378Fatigue
HP:0012649Increased inflammatory response
Частый (30–79%)6
HP:0001649Tachycardia
HP:0002615Hypotension
HP:0003326Myalgia
HP:0004396Poor appetite
HP:0030356Increased serum interferon-gamma level
HP:0030783Increased circulating interleukin 6 concentration
Периодический (5–29%)16
HP:0001289Confusion
HP:0002013Vomiting
HP:0002014Diarrhea
HP:0002018Nausea
HP:0002202Pleural effusion
HP:0002789Tachypnea
HP:0002904Hyperbilirubinemia
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0003259Elevated circulating creatinine concentration
HP:0011037Decreased urine output
HP:0011675Arrhythmia
HP:0012418Hypoxemia
HP:0012664Reduced left ventricular ejection fraction
HP:0012722Heart block
HP:0030005Capillary leak
HP:0100598Pulmonary edema
Очень редкий (1–4%)4
HP:0000988Skin rash
HP:0001919Acute kidney injury
HP:0002878Respiratory failure
HP:0005521Disseminated intravascular coagulation
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)