Livedoid vasculopathy
ORPHA:542643Clinical syndromeAdolescent, Adult
Фенотипы (HPO)49
Очень частый (80–99%)3
HP:0002814Abnormality of the lower limb
HP:0033260Livedo racemosa
HP:0200042Skin ulcer
Частый (30–79%)18
HP:0000953Hyperpigmentation of the skin
HP:0000965Cutis marmorata
HP:0001058Poor wound healing
HP:0001075Atrophic scars
HP:0001581Recurrent skin infections
HP:0001903Anemia
HP:0001977Abnormal thrombosis
HP:0002619Varicose veins
HP:0002960Autoimmunity
HP:0003029Enlargement of the ankles
HP:0003565Elevated erythrocyte sedimentation rate
HP:0005339Abnormality of complement system
HP:0007572Hyperpigmented streaks
HP:0010741Pedal edema
HP:0012514Lower limb pain
HP:0025016Abnormal capillary morphology
HP:0100585Telangiectasia of the skin
HP:0100724Hypercoagulability
Периодический (5–29%)21
HP:0000819Diabetes mellitus
HP:0000822Hypertension
HP:0001760Abnormal foot morphology
HP:0001976Reduced antithrombin III activity
HP:0002160Hyperhomocystinemia
HP:0003119Abnormal circulating lipid concentration
HP:0003401Paresthesia
HP:0003493Antinuclear antibody positivity
HP:0004855Reduced protein S activity
HP:0005293Venous insufficiency
HP:0005543Reduced protein C activity
HP:0025343Lupus anticoagulant
HP:0030350Erythematous papule
HP:0031190Superficial dermal perivascular inflammatory infiltrate
HP:0031364Ecchymosis
HP:0031365Macular purpura
HP:0032018Multiple mononeuropathy
HP:0040224Abnormality of fibrinolysis
HP:0040248Reduced plasminogen activator inhibitor 1 activity
HP:0100963Hyperesthesia
HP:0410008Abnormality of the peripheral nervous system
Очень редкий (1–4%)7
HP:0001876Pancytopenia
HP:0001901Polycythemia
HP:0001974Leukocytosis
HP:0002140Ischemic stroke
HP:0002725Systemic lupus erythematosus
HP:0012393Allergy
HP:0100647Graves disease
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | 1 | United States | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)