Leprosy
ORPHA:548DiseaseMultigenic/multifactorialAll ages
Фенотипы (HPO)47
Очень частый (80–99%)1
HP:0009830Peripheral neuropathy
Частый (30–79%)15
HP:0000962Hyperkeratosis
HP:0000966Hypohidrosis
HP:0002231Sparse body hair
HP:0003202Skeletal muscle atrophy
HP:0003401Paresthesia
HP:0003489Acute episodes of neuropathic symptoms
HP:0006121Acral ulceration
HP:0010829Impaired temperature sensition
HP:0010835Dissociated sensory loss
HP:0012181Entrapment neuropathy
HP:0012332Abnormal autonomic nervous system physiology
HP:0012645Enlarged peripheral nerve
HP:0020073Hypopigmented macule
HP:0034102Anti-sphingolipid antibody positivity
HP:0200036Skin nodule
Периодический (5–29%)20
HP:0000421Epistaxis
HP:0001026Penetrating foot ulcers
HP:0001324Muscle weakness
HP:0001596Alopecia
HP:0002087Abnormality of the upper respiratory tract
HP:0002223Absent eyebrow
HP:0003376Steppage gait
HP:0007460Autoamputation of digits
HP:0009027Foot dorsiflexor weakness
HP:0010827Abnormality of the seventh cranial nerve
HP:0011334Facial shape deformation
HP:0011457Loss of eyelashes
HP:0011821Abnormality of facial skeleton
HP:0012155Decreased corneal sensation
HP:0012185Constrictive median neuropathy
HP:0012500Verrucous papule
HP:0012534Dysesthesia
HP:0012804Corneal ulceration
HP:0030003Paralytic lagophthalmos
HP:0030351Urticarial plaque
Очень редкий (1–4%)11
HP:0000501Glaucoma
HP:0000554Uveitis
HP:0000618Blindness
HP:0000771Gynecomastia
HP:0000834Abnormality of the adrenal glands
HP:0001101Iritis
HP:0001392Abnormality of the liver
HP:0001743Abnormality of the spleen
HP:0005561Abnormality of bone marrow cell morphology
HP:0032404Testicular mass
HP:0100583Corneal perforation
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
| Annual incidence | 1-9 / 100 000 | 3.7 | Worldwide | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)