IgG4-related thyroid disease
ORPHA:64744Clinical subtypeNot applicableAdult
Фенотипы (HPO)25
Очень частый (80–99%)2
HP:0000853Goiter
HP:0100646Thyroiditis
Частый (30–79%)5
HP:0000821Hypothyroidism
HP:0000872Hashimoto thyroiditis
HP:0025379Anti-thyroid peroxidase antibody positivity
HP:0032069Anti-thyroglobulin antibody positivity
HP:0032300Increased circulating IgG4 level
Периодический (5–29%)8
HP:0001605Vocal cord paralysis
HP:0002015Dysphagia
HP:0002777Tracheal stenosis
HP:0002901Hypocalcemia
HP:0002960Autoimmunity
HP:0005994Nodular goiter
HP:0009798Euthyroid goiter
HP:0100647Graves disease
Очень редкий (1–4%)8
HP:0005200Retroperitoneal fibrosis
HP:0011784Thyrotoxicosis with diffuse goiter
HP:0012503Abnormality of the pituitary gland
HP:0030991Sclerosing cholangitis
HP:0031281Sialadenitis
HP:0032039Abnormality of the ocular adnexa
HP:0045026Abnormality of the mediastinum
HP:0100732Pancreatic fibrosis
Исключён (0%)2
HP:0002664Neoplasm
HP:0012393Allergy
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | 1.06 | United States | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)