Progressive supranuclear palsy
ORPHA:683DiseaseNot applicableAdult, Elderly
Фенотипы (HPO)32
Очень частый (80–99%)9
HP:0000605Supranuclear gaze palsy
HP:0000623Supranuclear ophthalmoplegia
HP:0002015Dysphagia
HP:0002172Postural instability
HP:0002317Unsteady gait
HP:0002527Falls
HP:0002529Neuronal loss in central nervous system
HP:0012535Abnormal synaptic transmission
HP:0100710Impulsivity
Частый (30–79%)19
HP:0000505Visual impairment
HP:0000511Vertical supranuclear gaze palsy
HP:0000514Slow saccadic eye movements
HP:0000643Blepharospasm
HP:0000712Emotional lability
HP:0000716Depression
HP:0000737Irritability
HP:0000741Apathy
HP:0000750Delayed speech and language development
HP:0001260Dysarthria
HP:0001332Dystonia
HP:0002067Bradykinesia
HP:0002120Cerebral cortical atrophy
HP:0002171Gliosis
HP:0002200Pseudobulbar signs
HP:0002321Vertigo
HP:0002354Memory impairment
HP:0002381Aphasia
HP:0100543Cognitive impairment
Периодический (5–29%)4
HP:0000496Abnormality of eye movement
HP:0000726Dementia
HP:0001337Tremor
HP:0002063Rigidity
Эпидемиология10
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | 0.65 | Worldwide | Value and class |
| Point prevalence | 1-9 / 100 000 | 5.26 | Worldwide | Value and class |
| Point prevalence | 1-5 / 10 000 | 14 | Europe | Value and class |
| Point prevalence | 1-9 / 100 000 | 1.39 | United States | Value and class |
| Point prevalence | 1-9 / 100 000 | 3.2 | Italy | Value and class |
| Point prevalence | 1-5 / 10 000 | 14 | Guadeloupe | Value and class |
| Point prevalence | 1-9 / 100 000 | 3.75 | United Kingdom | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.3 | Libyan Arab Jamahiriya | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.63 | United States | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.4 | Australia | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)