Chronic thromboembolic pulmonary hypertension
ORPHA:70591DiseaseNot applicableAdolescent, Adult, Elderly
Фенотипы (HPO)37
Очень частый (80–99%)3
HP:0001635Congestive heart failure
HP:0002092Pulmonary arterial hypertension
HP:0005317Increased pulmonary vascular resistance
Частый (30–79%)7
HP:0001962Palpitations
HP:0002204Pulmonary embolism
HP:0002625Deep venous thrombosis
HP:0002792Reduced vital capacity
HP:0002875Exertional dyspnea
HP:0012378Fatigue
HP:0030877Reduced FEV1/FVC ratio
Периодический (5–29%)23
HP:0000716Depression
HP:0000969Edema
HP:0001279Syncope
HP:0001513Obesity
HP:0001693Cardiac shunt
HP:0001708Right ventricular failure
HP:0001871Abnormality of blood and blood-forming tissues
HP:0002960Autoimmunity
HP:0003613Antiphospholipid antibody positivity
HP:0004831Recurrent thromboembolism
HP:0005133Right ventricular dilatation
HP:0005135Abnormal T-wave
HP:0005162Abnormal left ventricular function
HP:0010536Central sleep apnea
HP:0011227Elevated circulating C-reactive protein concentration
HP:0011712Right bundle branch block
HP:0011901Dysfibrinogenemia
HP:0012146Abnormality of von Willebrand factor
HP:0012184Increased HDL cholesterol concentration
HP:0012417Hypocapnia
HP:0025343Lupus anticoagulant
HP:0030718Right atrial enlargement
HP:0030977Increased factor VIII activity
Очень редкий (1–4%)4
HP:0002037Inflammation of the large intestine
HP:0002664Neoplasm
HP:0002754Osteomyelitis
HP:0005547Myeloproliferative disorder
Эпидемиология4
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
| Annual incidence | 1-9 / 100 000 | 4.2 | Europe | Value and class |
| Annual incidence | 1-9 / 100 000 | 5.1 | United States | Value and class |
| Annual incidence | 1-9 / 100 000 | 1.9 | Japan | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)