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Phenylketonuria

ORPHA:716DiseaseAutosomal recessiveInfancy

Фенотипы (25)

Очень частый (80–99%)1
HP:0032351Phenylalaninuria
Частый (30–79%)14
HP:0000252Microcephaly
HP:0000708Atypical behavior
HP:0000938Osteopenia
HP:0000964Eczematoid dermatitis
HP:0001010Hypopigmentation of the skin
HP:0001250Seizure
HP:0001263Global developmental delay
HP:0001328Specific learning disability
HP:0001510Growth delay
HP:0002353EEG abnormality
HP:0002500Abnormal cerebral white matter morphology
HP:0004923Hyperphenylalaninemia
HP:0010864Intellectual disability, severe
HP:0410021Musty odor
Периодический (5–29%)10
HP:0000716Depression
HP:0000726Dementia
HP:0000736Short attention span
HP:0000739Anxiety
HP:0001251Ataxia
HP:0001298Encephalopathy
HP:0001337Tremor
HP:0002061Lower limb spasticity
HP:0030680Abnormal cardiovascular system morphology
HP:0100704Cerebral visual impairment

Эпидемиология (103)

Prevalence at birth
1-9 / 100 000
France
Point prevalence
1-5 / 10 000
France
Prevalence at birth
1-5 / 10 000
Europe
Point prevalence
1-5 / 10 000
Europe
Prevalence at birth
1-9 / 100 000
United Kingdom
Point prevalence
1-5 / 10 000
United Kingdom
Prevalence at birth
1-5 / 10 000
Ireland
Point prevalence
1-5 / 10 000
Ireland
Prevalence at birth
1-9 / 1 000 000
Finland
Point prevalence
1-9 / 1 000 000
Finland
Prevalence at birth
1-9 / 100 000
United States
Point prevalence
1-9 / 100 000
United States
Prevalence at birth
1-9 / 100 000
Latin America
Point prevalence
1-9 / 100 000
Latin America
Prevalence at birth
1-9 / 100 000
Brazil
Point prevalence
1-9 / 100 000
Brazil
Prevalence at birth
1-9 / 100 000
Australia
Point prevalence
1-9 / 100 000
Australia
Prevalence at birth
1-5 / 10 000
Iceland
Point prevalence
1-5 / 10 000
Iceland
Prevalence at birth
1-9 / 100 000
Japan
Point prevalence
1-9 / 1 000 000
Japan
Prevalence at birth
1-9 / 100 000
China
Point prevalence
1-9 / 100 000
China
Prevalence at birth
1-9 / 100 000
Thailand
Point prevalence
1-9 / 1 000 000
Thailand
Prevalence at birth
1-9 / 100 000
Turkey
Point prevalence
1-5 / 10 000
Turkey
Prevalence at birth
1-9 / 100 000
United Arab Emirates
Point prevalence
1-9 / 100 000
United Arab Emirates
Point prevalence
1-5 / 10 000
Jordan
Prevalence at birth
1-9 / 100 000
Jordan
Point prevalence
1-9 / 100 000
India
Point prevalence
1-9 / 100 000
Korea, Republic of
Point prevalence
1-9 / 1 000 000
Philippines
Point prevalence
1-9 / 100 000
Singapore
Point prevalence
1-9 / 100 000
Taiwan, Province of China
Point prevalence
1-9 / 100 000
Bahrain
Point prevalence
1-5 / 10 000
Iran, Islamic Republic of
Point prevalence
1-9 / 100 000
Iraq
Point prevalence
1-5 / 10 000
Israel
Point prevalence
1-9 / 100 000
Saudi Arabia
Point prevalence
1-5 / 10 000
Egypt
Point prevalence
1-5 / 10 000
Tunisia
Point prevalence
1-5 / 10 000
Austria
Point prevalence
1-5 / 10 000
Belarus
Point prevalence
1-5 / 10 000
Bosnia and Herzegovina
Point prevalence
1-9 / 100 000
Bulgaria
Point prevalence
1-5 / 10 000
Croatia
Point prevalence
1-9 / 100 000
Cyprus
Point prevalence
1-5 / 10 000
Czech Republic
Point prevalence
1-9 / 100 000
Denmark
Point prevalence
1-5 / 10 000
Estonia
Point prevalence
1-5 / 10 000
Germany
Point prevalence
1-9 / 100 000
Greece
Point prevalence
1-5 / 10 000
Hungary
Point prevalence
1-5 / 10 000
Italy
Point prevalence
1-5 / 10 000
Latvia
Point prevalence
1-5 / 10 000
Lithuania
Point prevalence
1-5 / 10 000
Moldova, Republic of
Point prevalence
1-9 / 100 000
Netherlands
Point prevalence
1-9 / 100 000
Norway
Point prevalence
1-5 / 10 000
Poland
Point prevalence
1-9 / 100 000
Portugal
Point prevalence
1-5 / 10 000
Romania
Point prevalence
1-5 / 10 000
Russian Federation
Point prevalence
1-9 / 100 000
Serbia
Point prevalence
1-5 / 10 000
Slovakia
Point prevalence
1-9 / 100 000
Slovenia
Point prevalence
1-9 / 100 000
Spain
Point prevalence
1-9 / 100 000
Sweden
Point prevalence
1-5 / 10 000
Switzerland
Point prevalence
1-5 / 10 000
Ukraine
Point prevalence
1-9 / 100 000
Canada
Point prevalence
1-9 / 100 000
New Caledonia
Point prevalence
1-9 / 100 000
New Zealand
Point prevalence
1-9 / 100 000
Argentina
Point prevalence
1-9 / 100 000
Chile
Point prevalence
1-9 / 100 000
Costa rica
Point prevalence
1-9 / 100 000
Mexico
Point prevalence
1-9 / 100 000
Peru
Point prevalence
1-9 / 100 000
Cuba
Point prevalence
1-9 / 100 000
Worldwide
Prevalence at birth
1-5 / 10 000
India
Prevalence at birth
1-5 / 10 000
Pakistan
Prevalence at birth
1-9 / 100 000
Saudi Arabia
Prevalence at birth
1-9 / 100 000
Austria
Prevalence at birth
1-5 / 10 000
Estonia
Prevalence at birth
1-9 / 100 000
Germany
Prevalence at birth
1-9 / 100 000
Greece
Prevalence at birth
1-9 / 100 000
Hungary
Prevalence at birth
1-9 / 100 000
Italy
Prevalence at birth
1-5 / 10 000
North Macedonia
Prevalence at birth
1-9 / 100 000
Poland
Prevalence at birth
1-9 / 100 000
Portugal
Prevalence at birth
1-5 / 10 000
Slovakia
Prevalence at birth
1-9 / 100 000
Spain
Prevalence at birth
1-9 / 100 000
Chile
Prevalence at birth
1-9 / 100 000
Iran, Islamic Republic of
Prevalence at birth
1-9 / 100 000
Canada
Prevalence at birth
1-9 / 100 000
Korea, Republic of
Prevalence at birth
1-9 / 100 000
Taiwan, Province of China
Prevalence at birth
1-9 / 100 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы