Relapsing polychondritis
ORPHA:728DiseaseUnknownAll ages
Фенотипы (HPO)53
Очень частый (80–99%)5
HP:0000518Cataract
HP:0001369Arthritis
HP:0005310Large vessel vasculitis
HP:0100662Chondritis
HP:0200047Chondritis of pinna
Частый (30–79%)13
HP:0000360Tinnitus
HP:0001251Ataxia
HP:0001376Limitation of joint mobility
HP:0001609Hoarse voice
HP:0001646Abnormal aortic valve morphology
HP:0001701Pericarditis
HP:0002017Nausea and vomiting
HP:0002094Dyspnea
HP:0002321Vertigo
HP:0002786Tracheobronchomalacia
HP:0012735Cough
HP:0030828Wheezing
HP:0100750Atelectasis
Периодический (5–29%)35
HP:0000083Renal insufficiency
HP:0000093Proteinuria
HP:0000407Sensorineural hearing impairment
HP:0000491Keratitis
HP:0000509Conjunctivitis
HP:0000520Proptosis
HP:0000554Uveitis
HP:0000790Hematuria
HP:0000979Purpura
HP:0001545Anteriorly placed anus
HP:0001596Alopecia
HP:0001601Laryngomalacia
HP:0001686Loss of voice
HP:0002617Dilatation
HP:0002793Abnormal pattern of respiration
HP:0002829Arthralgia
HP:0002923Rheumatoid factor positive
HP:0003493Antinuclear antibody positivity
HP:0004306Abnormality of the endocardium
HP:0004418Thrombophlebitis
HP:0004422Biparietal narrowing
HP:0004936Venous thrombosis
HP:0006824Cranial nerve paralysis
HP:0010783Erythema
HP:0011107Recurrent aphthous stomatitis
HP:0012115Hepatitis
HP:0012733Macule
HP:0012819Myocarditis
HP:0031481Abnormal mitral valve physiology
HP:0033380Nasal chondritis
HP:0100532Scleritis
HP:0100533Inflammatory abnormality of the eye
HP:0100534Episcleritis
HP:0100758Gangrene
HP:0100820Glomerulopathy
Эпидемиология5
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.35 | United States | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.35 | Worldwide | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
| Annual incidence | <1 / 1 000 000 | 0.071 | United Kingdom | Value and class |
| Point prevalence | 1-9 / 1 000 000 | 0.52 | United Kingdom | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)