Polymyositis
ORPHA:732DiseaseNot applicableAdult, Elderly
Фенотипы (HPO)60
Очень частый (80–99%)9
HP:0001252Hypotonia
HP:0002829Arthralgia
HP:0002960Autoimmunity
HP:0003236Elevated circulating creatine kinase concentration
HP:0003457EMG abnormality
HP:0003701Proximal muscle weakness
HP:0004303Abnormal muscle fiber morphology
HP:0012544Elevated circulating aldolase concentration
HP:0012735Cough
Частый (30–79%)21
HP:0001369Arthritis
HP:0001824Weight loss
HP:0001945Fever
HP:0002019Constipation
HP:0002039Anorexia
HP:0002093Respiratory insufficiency
HP:0002875Exertional dyspnea
HP:0003326Myalgia
HP:0003493Antinuclear antibody positivity
HP:0006530Abnormal pulmonary interstitial morphology
HP:0012378Fatigue
HP:0033713Anti-signal recognition particle antibody positivity
HP:0034143Anti-threonyl-tRNA synthetase antibody positivity
HP:0034145Anti-alanyl-tRNA synthetase antibody positivity
HP:0034146Anti-glycyl tRNA-synthetase antibody positivity
HP:0034147Anti-aminoacyl-tRNA synthetase antibody positivity
HP:0034148Anti-isoleucyl tRNA-synthetase antibody positivity
HP:0034149Anti-phenylalanyl tRNA synthetase antibody positivity
HP:0034150Anti-tyrosyl-tRNA synthetase antibody positivity
HP:0034151Anti-asparaginyl-tRNA synthetase antibody positivity
HP:0034152Anti-histidyl tRNA synthetase antibody positivity
Периодический (5–29%)30
HP:0000091Abnormal renal tubule morphology
HP:0000934Chondrocalcinosis
HP:0000988Skin rash
HP:0001288Gait disturbance
HP:0001315Reduced tendon reflexes
HP:0001608Abnormality of the voice
HP:0001611Hypernasal speech
HP:0001618Dysphonia
HP:0001633Abnormal mitral valve morphology
HP:0001635Congestive heart failure
HP:0001639Hypertrophic cardiomyopathy
HP:0001644Dilated cardiomyopathy
HP:0001658Myocardial infarction
HP:0001701Pericarditis
HP:0001894Thrombocytosis
HP:0002020Gastroesophageal reflux
HP:0002027Abdominal pain
HP:0002068Neuromuscular dysphagia
HP:0002206Pulmonary fibrosis
HP:0002239Gastrointestinal hemorrhage
HP:0002240Hepatomegaly
HP:0002633Vasculitis
HP:0003565Elevated erythrocyte sedimentation rate
HP:0004936Venous thrombosis
HP:0005150Abnormal atrioventricular conduction
HP:0011675Arrhythmia
HP:0030880Raynaud phenomenon
HP:0031352Chest tightness
HP:0100595Camptocormia
HP:0100827Lymphocytosis
Эпидемиология8
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.585 | Europe | Value and class |
| Point prevalence | 1-9 / 100 000 | 7.1 | Europe | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.75 | Argentina | Value and class |
| Point prevalence | 1-9 / 100 000 | 7.2 | Argentina | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.41 | Australia | Value and class |
| Point prevalence | 1-9 / 100 000 | 7.2 | Australia | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.39 | Spain | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.76 | Sweden | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)