Tropical endomyocardial fibrosis
ORPHA:75565DiseaseNot applicableAdolescent, Adult, Childhood
Фенотипы (HPO)48
Облигатный (100%)1
HP:0006685Endocardial fibrosis
Очень частый (80–99%)4
HP:0001723Restrictive cardiomyopathy
HP:0002094Dyspnea
HP:0003115Abnormal EKG
HP:0012378Fatigue
Частый (30–79%)21
HP:0001541Ascites
HP:0001640Cardiomegaly
HP:0001678Atrioventricular block
HP:0001945Fever
HP:0002240Hepatomegaly
HP:0003073Hypoalbuminemia
HP:0004326Cachexia
HP:0004395Malnutrition
HP:0006677Prolonged QRS complex
HP:0011675Arrhythmia
HP:0011712Right bundle branch block
HP:0011713Left bundle branch block
HP:0012249Abnormal ST segment
HP:0012398Peripheral edema
HP:0012764Orthopnea
HP:0025077Decreased QRS voltage
HP:0025168Left ventricular diastolic dysfunction
HP:0030950Pulmonary venous hypertension
HP:0031295Left atrial enlargement
HP:0031664Systolic heart murmur
HP:0033114Quadruple gallop rhythm
Периодический (5–29%)20
HP:0000520Proptosis
HP:0001653Mitral regurgitation
HP:0001744Splenomegaly
HP:0001880Eosinophilia
HP:0001907Thromboembolism
HP:0004749Atrial flutter
HP:0004755Supraventricular tachycardia
HP:0005110Atrial fibrillation
HP:0005135Abnormal T-wave
HP:0005180Tricuspid regurgitation
HP:0006690Myocardial calcification
HP:0010741Pedal edema
HP:0011663Right ventricular cardiomyopathy
HP:0012664Reduced left ventricular ejection fraction
HP:0030057Autoimmune antibody positivity
HP:0030149Cardiogenic shock
HP:0030783Increased circulating interleukin 6 concentration
HP:0030848Elevated jugular venous pressure
HP:0031595Abnormal P wave
HP:0031650Abnormal atrioventricular valve physiology
Очень редкий (1–4%)2
HP:0005145Coronary artery stenosis
HP:0031601P pulmonale
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)