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Bickerstaff brainstem encephalitis

ORPHA:79138DiseaseNot applicableAll ages

Фенотипы (47)

Очень частый (80–99%)8
HP:0000602Ophthalmoplegia
HP:0001251Ataxia
HP:0001289Confusion
HP:0002329Drowsiness
HP:0003403EMG: decremental response of compound muscle action potential to repetitive nerve stimulation
HP:0003431Decreased motor nerve conduction velocity
HP:0007305CNS demyelination
HP:0032169Severe infection
Частый (30–79%)15
HP:0000651Diplopia
HP:0001284Areflexia
HP:0002090Pneumonia
HP:0002094Dyspnea
HP:0002270Abnormality of the autonomic nervous system
HP:0002353EEG abnormality
HP:0002922Increased CSF protein concentration
HP:0003690Limb muscle weakness
HP:0007131Acute demyelinating polyneuropathy
HP:0007209Facial paralysis
HP:0007256Abnormal pyramidal sign
HP:0011947Respiratory tract infection
HP:0012534Dysesthesia
HP:0012696Abnormal thalamic MRI signal intensity
HP:0030057Autoimmune antibody positivity
Периодический (5–29%)24
HP:0000496Abnormality of eye movement
HP:0000508Ptosis
HP:0000639Nystagmus
HP:0001259Coma
HP:0001283Bulbar palsy
HP:0001291Abnormal cranial nerve morphology
HP:0001315Reduced tendon reflexes
HP:0001348Brisk reflexes
HP:0002273Tetraparesis
HP:0002445Tetraplegia
HP:0002878Respiratory failure
HP:0003487Babinski sign
HP:0004887Respiratory failure requiring assisted ventilation
HP:0009916Anisocoria
HP:0010628Facial palsy
HP:0010831Impaired proprioception
HP:0010871Sensory ataxia
HP:0011499Mydriasis
HP:0012229CSF pleocytosis
HP:0012416Hypercapnia
HP:0012531Pain
HP:0030319Weakness of facial musculature
HP:0031123Recurrent gastroenteritis
HP:0100786Hypersomnia

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы