Japanese encephalitis
ORPHA:79139DiseaseNot applicableAll ages
Фенотипы (HPO)82
Очень частый (80–99%)3
HP:0001945Fever
HP:0002353EEG abnormality
HP:0002383Infectious encephalitis
Частый (30–79%)28
HP:0000273Facial grimacing
HP:0000298Mask-like facies
HP:0002013Vomiting
HP:0002039Anorexia
HP:0002069Bilateral tonic-clonic seizure
HP:0002315Headache
HP:0002396Cogwheel rigidity
HP:0002516Increased intracranial pressure
HP:0002922Increased CSF protein concentration
HP:0003202Skeletal muscle atrophy
HP:0003326Myalgia
HP:0003431Decreased motor nerve conduction velocity
HP:0003444EMG: chronic denervation signs
HP:0003470Paralysis
HP:0003496Increased circulating IgM level
HP:0004302Functional motor deficit
HP:0004372Reduced consciousness/confusion
HP:0007277Paucity of anterior horn motor neurons
HP:0009053Distal lower limb muscle weakness
HP:0010549Weakness due to upper motor neuron dysfunction
HP:0010702Increased circulating antibody level
HP:0011897Neutrophilia
HP:0012229CSF pleocytosis
HP:0012378Fatigue
HP:0012692Focal T2 hyperintense thalamic lesion
HP:0025143Chills
HP:0040272Hyperintensity of MRI T2 signal of the spinal cord
HP:0200149CSF lymphocytic pleiocytosis
Периодический (5–29%)51
HP:0000639Nystagmus
HP:0000708Atypical behavior
HP:0001259Coma
HP:0001266Choreoathetosis
HP:0001276Hypertonia
HP:0001287Meningitis
HP:0001332Dystonia
HP:0001336Myoclonus
HP:0001337Tremor
HP:0001762Talipes equinovarus
HP:0002014Diarrhea
HP:0002027Abdominal pain
HP:0002060Abnormal cerebral morphology
HP:0002071Abnormality of extrapyramidal motor function
HP:0002098Respiratory distress
HP:0002133Status epilepticus
HP:0002179Opisthotonus
HP:0002181Cerebral edema
HP:0002203Respiratory paralysis
HP:0002339Abnormal caudate nucleus morphology
HP:0002418Abnormality of midbrain morphology
HP:0002463Language impairment
HP:0002793Abnormal pattern of respiration
HP:0002816Genu recurvatum
HP:0002902Hyponatremia
HP:0002987Elbow flexion contracture
HP:0003781Excessive salivation
HP:0007361Abnormality of the pons
HP:0007695Abnormal pupillary light reflex
HP:0007941Limited extraocular movements
HP:0008959Distal upper limb muscle weakness
HP:0010543Opsoclonus
HP:0010546Muscle fibrillation
HP:0010547Muscle flaccidity
HP:0010628Facial palsy
HP:0010663Abnormality of thalamus morphology
HP:0010851EEG with burst suppression
HP:0010864Intellectual disability, severe
HP:0011153Focal motor seizure
HP:0011182Interictal epileptiform activity
HP:0011468Facial tics
HP:0012195Irregular respiration
HP:0012502Abnormality of the internal capsule
HP:0025145Rigors
HP:0025258Stiff neck
HP:0025387Pill-rolling tremor
HP:0030826Eyelid fasciculation
HP:0031218Inappropriate antidiuretic hormone secretion
HP:0045007Abnormality of the substantia nigra
HP:0100543Cognitive impairment
HP:0100598Pulmonary edema
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.65 | Europe | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)