← Назад

HJV or HAMP-related hemochromatosis

ORPHA:79230DiseaseAutosomal recessiveAdolescent, Adult, Childhood

Ассоциированные гены (2)

HJV
hemojuvelin BMP co-receptor
Disease-causing germline mutation(s) (loss of function) in
OMIM: 608374
HAMP
hepcidin antimicrobial peptide
Disease-causing germline mutation(s) (loss of function) in
OMIM: 606464

Фенотипы (15)

Очень частый (80–99%)4
HP:0002612Congenital hepatic fibrosis
HP:0003281Increased circulating ferritin concentration
HP:0011031Abnormality of iron homeostasis
HP:0012463Elevated transferrin saturation
Частый (30–79%)9
HP:0000135Hypogonadism
HP:0000802Impotence
HP:0000819Diabetes mellitus
HP:0001254Lethargy
HP:0001324Muscle weakness
HP:0001644Dilated cardiomyopathy
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0003040Arthropathy
HP:0007440Generalized hyperpigmentation
Периодический (5–29%)2
HP:0000939Osteoporosis
HP:0012093Abnormality of endocrine pancreas physiology

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы