Acute disseminated encephalomyelitis
ORPHA:83597DiseaseNot applicableAll ages
Фенотипы (HPO)53
Облигатный (100%)1
HP:0001298Encephalopathy
Очень частый (80–99%)3
HP:0007204Diffuse white matter abnormalities
HP:0007305CNS demyelination
HP:0010845EEG with generalized slow activity
Частый (30–79%)23
HP:0000708Atypical behavior
HP:0000737Irritability
HP:0001250Seizure
HP:0001251Ataxia
HP:0001268Mental deterioration
HP:0001317Abnormal cerebellum morphology
HP:0001945Fever
HP:0002018Nausea
HP:0002134Abnormality of the basal ganglia
HP:0002143Abnormality of the spinal cord
HP:0002181Cerebral edema
HP:0002315Headache
HP:0002518Abnormal periventricular white matter morphology
HP:0002922Increased CSF protein concentration
HP:0007256Abnormal pyramidal sign
HP:0012486Myelitis
HP:0012696Abnormal thalamic MRI signal intensity
HP:0012747Abnormal brainstem MRI signal intensity
HP:0025373Interictal EEG abnormality
HP:0031696Disseminated viral infection
HP:0032492Anti-myelin oligodendrocyte glycoprotein antibody positivity
HP:0100786Hypersomnia
HP:0200149CSF lymphocytic pleiocytosis
Периодический (5–29%)17
HP:0000572Visual loss
HP:0000718Aggressive behavior
HP:0001259Coma
HP:0001269Hemiparesis
HP:0001289Confusion
HP:0001324Muscle weakness
HP:0002013Vomiting
HP:0002167Abnormality of speech or vocalization
HP:0003474Somatic sensory dysfunction
HP:0004887Respiratory failure requiring assisted ventilation
HP:0006824Cranial nerve paralysis
HP:0010843EEG with focal slow activity
HP:0011151Obtundation status
HP:0011193EEG with focal spikes
HP:0030857Eye movement-induced pain
HP:0031179Nuchal rigidity
HP:0100653Optic neuritis
Очень редкий (1–4%)9
HP:0004305Involuntary movements
HP:0006562Viral hepatitis
HP:0006597Diaphragmatic paralysis
HP:0007103Hypointensity of cerebral white matter on MRI
HP:0012302Herpes simplex encephalitis
HP:0020088Post-vaccination measles
HP:0020089Post-vaccination rubella
HP:0031693Severe Epstein Barr virus infection
HP:0031695Severe parainfluenza infection
Эпидемиология2
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.6 | Europe | Value and class |
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)