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VACTERL/VATER association

ORPHA:887Malformation syndromeNot applicableAntenatal, Neonatal

Ассоциированные гены (1)

HOXD13
homeobox D13
Candidate gene tested in
OMIM: 142989

Фенотипы (41)

Очень частый (80–99%)5
HP:0001561Polyhydramnios
HP:0001622Premature birth
HP:0002023Anal atresia
HP:0002777Tracheal stenosis
HP:0006703Aplasia/Hypoplasia of the lungs
Частый (30–79%)9
HP:0000086Ectopic kidney
HP:0000104Renal agenesis
HP:0000776Congenital diaphragmatic hernia
HP:0001601Laryngomalacia
HP:0001671Abnormal cardiac septum morphology
HP:0002575Tracheoesophageal fistula
HP:0003422Vertebral segmentation defect
HP:0006501Aplasia/Hypoplasia of the radius
HP:0030680Abnormal cardiovascular system morphology
Периодический (5–29%)27
HP:0000003Multicystic kidney dysplasia
HP:0000008Abnormal morphology of female internal genitalia
HP:0000028Cryptorchidism
HP:0000047Hypospadias
HP:0000048Bifid scrotum
HP:0000062Ambiguous genitalia
HP:0000126Hydronephrosis
HP:0000175Cleft palate
HP:0000239Large fontanelles
HP:0000772Abnormal rib morphology
HP:0000795Abnormality of the urethra
HP:0001048Cavernous hemangioma
HP:0001177Preaxial hand polydactyly
HP:0001195Single umbilical artery
HP:0001511Intrauterine growth retardation
HP:0001539Omphalocele
HP:0001732Abnormality of the pancreas
HP:0002085Occipital encephalocele
HP:0002323Anencephaly
HP:0005107Abnormal sacrum morphology
HP:0005108Abnormal intervertebral disk morphology
HP:0005264Abnormality of the gallbladder
HP:0006101Finger syndactyly
HP:0008736Hypoplasia of penis
HP:0012732Anorectal anomaly
HP:0100335Non-midline cleft of the upper lip
HP:0000358Posteriorly rotated ears

Эпидемиология (2)

Prevalence at birth
1-9 / 100 000
Europe
Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы