Acute liver failure
ORPHA:90062Clinical syndromeNot applicableAdolescent, Adult, Childhood, Elderly, Infancy
Фенотипы (HPO)50
Очень частый (80–99%)4
HP:0000952Jaundice
HP:0001404Hepatocellular necrosis
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0012115Hepatitis
Частый (30–79%)24
HP:0000712Emotional lability
HP:0000713Agitation
HP:0000846Adrenal insufficiency
HP:0000978Bruising susceptibility
HP:0001289Confusion
HP:0001350Slurred speech
HP:0001873Thrombocytopenia
HP:0001943Hypoglycemia
HP:0001987Hyperammonemia
HP:0002013Vomiting
HP:0002014Diarrhea
HP:0002018Nausea
HP:0002329Drowsiness
HP:0002605Hepatic necrosis
HP:0002614Hepatic periportal necrosis
HP:0002615Hypotension
HP:0002793Abnormal pattern of respiration
HP:0002795Abnormal respiratory system physiology
HP:0003225Reduced coagulation factor V activity
HP:0003256Abnormality of the coagulation cascade
HP:0008151Prolonged prothrombin time
HP:0008169Reduced factor VII activity
HP:0008321Reduced factor X activity
HP:0030977Increased factor VIII activity
Периодический (5–29%)22
HP:0000716Depression
HP:0000988Skin rash
HP:0001250Seizure
HP:0001251Ataxia
HP:0001259Coma
HP:0001298Encephalopathy
HP:0001892Abnormal bleeding
HP:0001919Acute kidney injury
HP:0001941Acidosis
HP:0001945Fever
HP:0001948Alkalosis
HP:0002170Intracranial hemorrhage
HP:0002181Cerebral edema
HP:0002239Gastrointestinal hemorrhage
HP:0002311Incoordination
HP:0002516Increased intracranial pressure
HP:0002625Deep venous thrombosis
HP:0002883Hyperventilation
HP:0007021Pain insensitivity
HP:0012417Hypocapnia
HP:0031273Shock
HP:0031844Euphoria
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 20 | Europe | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)