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Stickler syndrome type 1

ORPHA:90653Clinical subtypeAutosomal dominantChildhood, Infancy, Neonatal

Ассоциированные гены (1)

COL2A1
collagen type II alpha 1 chain
Disease-causing germline mutation(s) in
OMIM: 120140

Фенотипы (21)

Очень частый (80–99%)8
HP:0000327Hypoplasia of the maxilla
HP:0000343Long philtrum
HP:0000518Cataract
HP:0000541Retinal detachment
HP:0000545Myopia
HP:0002652Skeletal dysplasia
HP:0003196Short nose
HP:0004327Abnormal vitreous humor morphology
Частый (30–79%)11
HP:0000175Cleft palate
HP:0000407Sensorineural hearing impairment
HP:0000520Proptosis
HP:0000926Platyspondyly
HP:0001634Mitral valve prolapse
HP:0002758Osteoarthritis
HP:0002829Arthralgia
HP:0005930Abnormality of epiphysis morphology
HP:0100734Abnormality of vertebral epiphysis morphology
HP:6000015Tympanic membrane hypermobility
HP:0001382Joint hypermobility
Периодический (5–29%)2
HP:0000572Visual loss
HP:0001249Intellectual disability

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы