Simple cryoglobulinemia
ORPHA:91139DiseaseAdult, Elderly
Фенотипы (HPO)55
Очень частый (80–99%)3
HP:0000979Purpura
HP:0001871Abnormality of blood and blood-forming tissues
HP:0410135Cold urticaria
Частый (30–79%)12
HP:0001955Unexplained fevers
HP:0003496Increased circulating IgM level
HP:0006121Acral ulceration
HP:0007067Distal peripheral sensory neuropathy
HP:0007141Sensorimotor neuropathy
HP:0009830Peripheral neuropathy
HP:0011355Localized skin lesion
HP:0012378Fatigue
HP:0030880Raynaud phenomenon
HP:0031047Paraproteinemia
HP:0032018Multiple mononeuropathy
HP:0033260Livedo racemosa
Периодический (5–29%)18
HP:0000077Abnormality of the kidney
HP:0000083Renal insufficiency
HP:0000093Proteinuria
HP:0000793Membranoproliferative glomerulonephritis
HP:0000822Hypertension
HP:0001369Arthritis
HP:0001824Weight loss
HP:0002633Vasculitis
HP:0002829Arthralgia
HP:0002907Microscopic hematuria
HP:0003401Paresthesia
HP:0005508Monoclonal immunoglobulin M proteinemia
HP:0006775Multiple myeloma
HP:0010833Spontaneous pain sensation
HP:0011276Vascular skin abnormality
HP:0012191B-cell lymphoma
HP:0012574Mesangial hypercellularity
HP:0032290Monoclonal elevation of IgG
Очень редкий (1–4%)22
HP:0005550Chronic lymphatic leukemia
HP:0006562Viral hepatitis
HP:0006824Cranial nerve paralysis
HP:0011024Abnormality of the gastrointestinal tract
HP:0032335Monoclonal elevation of circulating IgA
HP:0000100Nephrotic syndrome
HP:0000123Nephritis
HP:0001250Seizure
HP:0001297Stroke
HP:0001627Abnormal heart morphology
HP:0001635Congestive heart failure
HP:0001658Myocardial infarction
HP:0001701Pericarditis
HP:0002011Morphological central nervous system abnormality
HP:0002027Abdominal pain
HP:0002088Abnormal lung morphology
HP:0002239Gastrointestinal hemorrhage
HP:0002315Headache
HP:0002344Progressive neurologic deterioration
HP:0002923Rheumatoid factor positive
HP:0004302Functional motor deficit
HP:0004431Complement deficiency
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)