Zollinger-Ellison syndrome
ORPHA:913DiseaseNot applicableAdult, Elderly
Фенотипы (HPO)34
Облигатный (100%)2
HP:0002044Zollinger-Ellison syndrome
HP:0100634Neuroendocrine neoplasm
Очень частый (80–99%)6
HP:0002014Diarrhea
HP:0002018Nausea
HP:0002574Episodic abdominal pain
HP:0002588Duodenal ulcer
HP:0004398Peptic ulcer
HP:0100633Esophagitis
Частый (30–79%)1
HP:0001824Weight loss
Периодический (5–29%)24
HP:0000843Hyperparathyroidism
HP:0000845Elevated circulating growth hormone concentration
HP:0000854Thyroid adenoma
HP:0000952Jaundice
HP:0001012Multiple lipomas
HP:0002239Gastrointestinal hemorrhage
HP:0002573Hematochezia
HP:0002893Pituitary adenoma
HP:0003072Hypercalcemia
HP:0003118Increased circulating cortisol level
HP:0003165Elevated circulating parathyroid hormone level
HP:0005214Intestinal obstruction
HP:0006767Pituitary prolactin cell adenoma
HP:0008208Parathyroid hyperplasia
HP:0008256Adrenocortical adenoma
HP:0008291Pituitary corticotropic cell adenoma
HP:0010783Erythema
HP:0011760Pituitary growth hormone cell adenoma
HP:0011761Pituitary null cell adenoma
HP:0012030Increased urinary cortisol level
HP:0012032Lipoma
HP:0012334Extrahepatic cholestasis
HP:0030404Glucagonoma
HP:0030688Increased glucagon level
Очень редкий (1–4%)1
HP:0006744Adrenocortical carcinoma
Эпидемиология6
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.15 | Europe | Value and class |
| Point prevalence | 1-9 / 100 000 | — | Europe | Class only |
| Annual incidence | 1-9 / 1 000 000 | 0.15 | Denmark | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.3 | Switzerland | Value and class |
| Annual incidence | <1 / 1 000 000 | 0.05 | Ireland | Value and class |
| Annual incidence | 1-9 / 1 000 000 | 0.125 | Worldwide | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)